Caspase-8 hampers pro-inflammatory gene expression induced by the cytosolic RNA sensor retinoic acid-inducible gene I (RIG-I) through cleavage of RIPK1, which is recruited to a …

2019年11月20日 · Caspase-8 is the initiator caspase of extrinsic apoptosis 1, 2 and inhibits necroptosis mediated by RIPK3 and MLKL. Accordingly, caspase-8 deficiency in mice causes …

Caspase-8-dependent cleavage and activation of the NLRP3 trigger the assembly of the inflammasome complex to enable cytokine release. Conversely, caspase-8 activation can …

In this review, we discuss the emerging crosstalk between cell death and innate immune cell inflammatory signalling, particularly focusing on novel non-apoptotic functions of caspase-8. …

2022年1月21日 · Caspase-8 is an initiator of death receptor-induced apoptosis and an inhibitor of RIPK3-MLKL-dependent necroptosis. In addition, caspase-8 has been implicated in...

Caspase-8 is a cysteine - aspartate specific protease that classically triggers the extrinsic apoptotic pathway, in response to the activation of cell surface Death Receptors (DRs) like …

Integral in the regulation and initiation of death receptor-mediated activation of programmed cell death is the aspartate-specific cysteine protease (caspase)-8. This review describes the role of …

Initially discovered as an initiator protease in apoptosis mediated by death receptors, caspase-8 is now known to have an apparently confounding opposing effect in securing cell survival. It is …

Caspase-8 is the initiator caspase of extrinsic apoptosis 1,2 and inhibits necroptosis mediated by RIPK3 and MLKL. Accordingly, caspase-8 deficiency in mice causes embryonic …

Caspase 8 is a cysteine protease that initiates apoptotic signaling via the extrinsic pathway and is differentially expressed in the peripheral immune system of MS patients (Comabella and …