TNF-α 主要由单核—巨噬细胞分泌； TNF-β 主要由活化的 T淋巴细胞 分泌。TNF在体内外均能刺激 IL-1 的产生，不耐热，70℃30min失活。 1975年Carswell等发现接种BCC的小鼠注射 LPS 后，血清中含有一种能杀伤某些肿瘤细胞或使体内肿瘤组织发生血坏死的因子，称为肿瘤 ...

Tumour necrosis factor (TNF) was initially described by Carswell et al (Proc Natl Acad Sci USA 72: 3666-3670, 1975) and was so named because of its massive lethal effect on some tumours, causing haemorrhagic necrosis, resulting in regression (Old LJ: Nature 326: 330-331, 1987). Two forms of TNF are …

When TNF was first isolated in 1975 by Carswell, Old and colleagues, it was identified as the factor responsible for endotoxin-induced haemorrhagic necrosis of experimental tumours 21. The line of research leading to the isolation of TNF can be traced back to William Coley’s use of bacterial extracts to treat patients with cancer starting in ...

1975年E.A. Carswell等人发现接种卡介苗的小鼠注射细菌脂多糖后，血清中出现一种能使多种肿瘤发生出血性坏死的物质，将其命名为肿瘤坏死因子（tumor necrosis factor，TNF)。

一、TNF超家族 . 1975年Carswell等人首次发现在接种BCG的小鼠中注射LPS后，血清中得到一种可以直接杀伤肿瘤细胞，但对正常细胞没有明显的细胞毒性的细胞因子，称之为肿瘤坏死因子（tumor necrosis factor, TNF）。

2015年5月26日 · TNF activity was described by Carswell in 1975, and the molecule was later cloned, purified and initially characterized by Aggarwal and colleagues in the mid-1980s 1, 2, 3. These important...

2009年4月3日 · Tumour necrosis factor (TNF) is a major inflammatory cytokine that was first identified for its ability to induce rapid haemorrhagic necrosis of experimental cancers.

1、TNF 简介. 肿瘤坏死因子(tumor necrosis factor，TNF) , 1975年E.A. Carswell等人发现接种卡介苗的小鼠注射细菌脂多糖后，血清中出现一种能使多种肿瘤发生出血性坏死的物质，将其命名为肿瘤坏死因子。

carswell, e.a., endotoxin-induced serum factor that causes necrosis of tumors, proceedings of the national academy of sciences of the united states of america 72: 3666 (1975).

TNF-positive serum is as effective as endotoxin itself in causing necrosis of the sarcoma Meth A and other transplanted tumors. A variety of tests indicate that TNF is not residual endotoxin, but a factor released from host cells, probably macrophages, by endotoxin.