Carbapenems are a class of very effective antibiotic agents most commonly used for treatment of severe bacterial infections. This class of antibiotics is usually reserved for known or suspected multidrug-resistant (MDR) bacterial infections.

Carbapenems are a class of beta-lactam antibiotic that are active against many aerobic and anaerobic gram-positive and gram-negative organisms. Thienamycin was the first carbapenem to be discovered in 1976.

Carbapenems are broad-spectrum antibiotics. That is, they are effective against many types of bacteria, including bacteria that are resistant to many other antibiotics. Carbapenems must be …

2021年11月7日 · Carbapenemases are β-lactamases with versatile hydrolytic capacities. They have the ability to hydrolyze penicillins, cephalosporins, monobactams, and carbapenems. Bacteria producing these β-lactamases may cause serious infections in which the carbapenemase activity renders many β-lactams ineffective.

2011年8月22日 · Carbapenems play a critically important role in our antibiotic armamentarium. Of the many hundreds of different β-lactams, carbapenems possess the broadest spectrum of activity and greatest potency against Gram-positive and Gram-negative bacteria.

Carbapenems are potent members of the β-lactam family that inhibit bacterial cell-wall biosynthesis inhibitors . They are highly effective against Gram-negative and Gram-positive drug-resistant infections . As such, carbapenems are typically reserved as an antibiotic of last resort. The WHO lists meropenem as an essential medicine.

2023年5月11日 · Carbapenems are members of the β-Lactam antibiotic class. Molecularly defining, carbapenems are antibiotics having β– lactam ring with sulfur at the C-1 position and a double bond between C-2 and C-3 of the ring with the side chains arranged in the Trans- position.

2023年5月12日 · Carbapenemases are the β-lactamase enzymes that hydrolyze most of the β-lactam antibiotics, including carbapenems. They are the most potent β- lactamases having a very wide spectrum of activity against penicillins, cephalosporins, monobactams, and carbapenems.

碳青霉烯类抗生素是抗菌谱最广，抗菌活性最强的非典型β-内酰胺抗生素，因其具有对 β-内酰胺酶 稳定以及毒性低等特点，已经成为治疗严重细菌感染最主要的 抗菌药物 之一。 其结构与 青霉素 类的青霉环相似，不同之处在于噻唑环上的硫原子为碳所替代，且C2与C3之间存在不饱和双键（见图）；另外，其6位羟乙基侧链为反式构象。 研究证明，正是这个构型特殊的基团，使该类化合物与通常青霉烯的顺式构象显著不同，具有超广谱的、极强的抗菌活性，以及对β-内酰胺酶高度 …

Carbapenems are parenteral bactericidal beta-lactam antibiotics that have an extremely broad spectrum. They are active against. Most Enterococcus faecalis and many Pseudomonas aeruginosa strains, including those resistant to broad-spectrum penicillins and cephalosporins, are susceptible to imipenem and meropenem but are resistant to ertapenem.