6 天之前 · CAPN2 (Calpain 2) is a Protein Coding gene. Diseases associated with CAPN2 include Oculopharyngodistal Myopathy 2 and Amelogenesis Imperfecta, Hypomaturation Type, Iia2. Among its related pathways are Defective Intrinsic Pathway for Apoptosis and DREAM Repression and Dynorphin Expression.

2024年11月27日 · Title: CAPN2 promotes apalutamide resistance in metastatic hormone-sensitive prostate cancer by activating protective autophagy. Rare variants in CAPN2 increase risk for isolated hypoplastic left heart syndrome.

Calpain-2 catalytic subunit is a protein that in humans is encoded by the CAPN2 gene. [5][6] The calpains, calcium-activated neutral proteases, are nonlysosomal, intracellular cysteine proteases. The mammalian calpains include ubiquitous, stomach-specific, and muscle-specific proteins.

2016年3月22日 · Calpain I and calpain II are heterodimers with distinct large subunits, encoded by the CAPN1 (114220) and CAPN2 genes, respectively, associated with a common small subunit (CAPNS1; 114170). By screening a human skeletal muscle cDNA library using the large subunits of rabbit and chicken CANP as probes, Imajoh et al. (1988) cloned CAPN2.

钙蛋白酶是钙激活的中性蛋白酶，是非溶酶体细胞内半胱氨酸蛋白酶。 哺乳动物钙蛋白酶包括普遍存在的胃特异性和肌肉特异性蛋白质。 无处不在的酶由异二聚体组成，这些异二聚体具有与共同的小调节亚基相关联的独特的大催化亚基。 该基因编码普遍存在的酶钙蛋白酶 2 的大亚基。 已报道 5' UTR 中的多个异质转录起始位点。 已发现该基因的两个转录本变体编码不同的亚型。 [RefSeq 提供，2009 年 3 月] The calpains, calcium-activated neutral proteases, are nonlysosomal, …

CAPN2的详细信息，包括基因名称，代码，染色体位置，相互作用关系和通路，简述为钙蛋白酶的，钙激活中性蛋白酶，是nonlysosomal，细胞内的半胱氨酸蛋白酶。

2025年2月8日 · CAPN2 acts as an indicator of hepatitis B virus to induce hepatic fibrosis. Calpain-2 participates in the process of calpain-1 inactivation. Heat stress reduces calpain-2 expression, which then activates p38, leading to cardiomyocyte apoptosis and heart dysfunction.

2024年10月6日 · Clinical resource with information about CAPN2, Common variants associated with general and MMR vaccine-related febrile seizures., and available tests. There are links to practice guidelines and authoritative resources like GeneReviews, PubMed, MedlinePlus, PharmGKB and clinicaltrials.gov.

钙激活中性蛋白酶（calpains）是一种非溶酶体的细胞内半胱氨酸蛋白酶，受钙离子调节。 哺乳动物的calpains包括泛素存在的、胃特异性的和肌肉特异性的蛋白质。 泛素存在的酶由具有不同大型催化亚基的异源二聚体组成，这些亚基与一个公共的小型调节亚基相关联。 这个基因编码泛素存在酶的大型亚基，即calpain 2。 在5'UTR中已经报道了多个不同的转录起始位点。 已经发现这个基因有两个编码不同异构体的转录变异体。 [RefSeq,2009年3月提供] Dir./Indir. Small molecule …

Calpains2 (CAPN2) is a calcium-dependent, non-lysosomal cysteine protease that plays critical roles in normal cellular functions and pathological processes, including tumorigenesis, cancer progression, and metastasis. However, the role and underlying regulatory mechanisms of CAPN2 in pancreatic cancer (PC) are still unknown.