PDEs 1和．2既能水解cAMP，又能水解cGMP，但PDE1因其亚型不同，对两种 底物 发挥不同的水解效能。 PDEs的氨基端调控区域具有高度异源性，反映PDE家族成员的不同的辅助因子。

磷酸二酯酶（PDE）具有水解细胞内第二信使（cAMP,环磷酸腺苷或cGMP,环磷酸鸟苷）的功能，降解细胞内cAMP或cGMP为5-单磷酸核苷（5’ AMP或5’GMP)，从而终结这些第二信使所传导的生化作用。

cAMP调节关键的生理过程，包括 代谢、分泌、钙平衡、肌肉收缩、细胞命运和基因转录。 cAMP直接作用于三个主要靶标： 蛋白激酶A （PKA）、被cAMP激活的交换蛋白（Epac）和 环核苷酸门控离子通道 （CNGCs）。

2021年1月7日 · Phosphodiesterases (PDEs) are enzymes involved in the homeostasis of both cAMP and cGMP. They are members of a family of proteins that includes 11 subfamilies with...

磷酸二酯酶 (PDEs) 是一系列水解cAMP 及 cGMP 的水解酶，是调节 cAMP 和 cGMP 水平的重要环节，针对 PDEs 尤其是 PDE3 和 PDE5 的干预对于心力衰竭治疗有着重要意义 环磷酸腺苷 (cAMP)与环磷酸鸟苷 (cGMP)是细胞内重…

2023年7月1日 · This review aims to evaluate data on cAMP-PDE signaling pathway and PDE4 inhibitors mechanism of action to elucidate the efficacy of targeting cAMP-PDE signaling pathway as a promising therapeutic strategy in COPD patients.

2007年6月8日 · The cAMP-hydrolyzing activity of several families of cyclic nucleotide phosphodiesterases found in human heart is regulated by cGMP. In the case of PDE2, this regulation primarily involves the allosteric stimulation of cAMP hydrolysis by cGMP. For PDE3, cGMP acts as a competitive inhibitor of cAMP hydrolysis.

2010年1月1日 · The PDEs constitute a superfamily of metal-dependent phosphohydrolases that catalyze hydrolysis of cAMP, cGMP, or both CNs to their respective 5′ non-cyclic forms. Of the 11 mammalian PDE families (PDEs 1–11), PDE4, PDE7, and PDE8 are highly specific for cAMP and are termed the cAMP-specific PDEs (cA-PDEs).

Phosphodiesterases (PDEs) are enzymes that regulate the intracellular levels of cAMP and cGMP. Protein kinase A or cAMP-dependent protein kinase mediates most cAMP effects in the cell. Over the last 25 years, various components of this group of molecules have been involved in human diseases, both genetic and acquired.

Introduction: PDEs are key enzymes in the adenosine and guanosine cyclic nucleotides (cAMP and cGMP) signaling cascade. Their inhibition increases cyclic nucleotide levels inside the cell. Thus, pharmacological modulation of PDE activity can have profound effects on the function of cells and organ systems throughout the body.