2021年3月11日 · The hematoxylin and eosin (H&E) and IHC staining of lung tissue sections demonstrated that mice bearing NRF2-knockdown Ca9-22-D1 cells significantly inhibited lung-specific metastatic tumor foci formation compared with mice bearing mock control cells, and NRF2 expression level is positively correlated with the number of tumor foci (Figure ...

c-MYC-directed NRF2 drives malignant progression of head and neck squamous cell carcinoma through glucose-6-phosphate dehydrogenase and transketolase activation

2017年3月10日 · Redox regulated Nrf2, HIF and NF-κB are important in cancer and during development. Nrf2, HIF and NF-κB are activated in conjunction with markers of cancer stem cells. Nrf2 and HIF are concurrently induced in the core of growing spheroids. Induction of HIF promotes a quiescent and resistant stem cell like phenotype. 1. Introduction.

2020年8月18日 · As predicted, CA9 knockdown increased MitoTracker staining intensity and enhanced the expressions of key factors in mitochondrial biogenesis, including peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α), nuclear factor erythroid 2-related factor 2 (NRF2), and mitochondrial transcription factor 1 (TFAM) (Figure 3 C,D ...

The S4 inhibitor, a 4-(3′-(3″,5″-dimethylphenyl)ureido)phenyl sulfamate inhibits tumor-associated carbonic anhydrases CA9 and CA12 while avoiding off targeting of the cytosolic CA1 and CA2 enzymes [39,40,41,42,43].

碳酸酐酶IX (carbonic anhydrase IX, CAIX，CA9)是一个由459个氨基酸组成的跨膜蛋白，由四个结构域组成：N端蛋白多糖样结构域（PG）、CA催化结构域（CA）、单通螺旋跨膜区和短的胞内尾巴。

2025年2月28日 · Upon activation, CA manifests electrophilic properties to stimulate the Nrf2 transcriptional pathway via reaction with Keap1. However, purified CA is readily oxidized and thus highly unstable. To develop CA as an Alzheimer’s disease (AD) therapeutic, we synthesized pro-drug derivatives, among which the di-acetylated form (diAcCA) showed ...

核因子（NRF2） 是一种转录因子，它通过表达参与氧化应激响应和药物解毒的基因有效调节细胞对 有毒物质和氧化损伤的防御能力。 NRF2的活动受到复杂的转录和翻译后网络的严格调控，使其能够协调细胞对各种病理性应激因素的响应和适应，从而维持细胞稳态。 一项研究表明，NRF2处于一个复杂调控网络的中心，这确立了NRF2作为一个真正的多效性转录因子的地位。 作为CNC转录因子家族的一员，NRF2由七个Neh域 (Nrf2 ECH 同源结构域) 组成，每个域具有不同的功 …

2016年11月8日 · Although the nuclear factor-erythroid 2-related factor 2 (NRF2) pathway is one of the most frequently dysregulated in cancer, it is not clear whether mutational status is a good predictor of...

2023年9月19日 · 该研究发现揭示DPP9通过竞争性结合KEAP1，稳定NRF2蛋白水平，激活氧化应激信号，抑制细胞铁死亡，从而诱导了ccRCC靶向治疗耐药。 研究人员发现，在ccRCC中，DPP9的mRNA和蛋白水平均显著上调，并且DPP9高表达与ccRCC患者的肿瘤分期和不良预后正 …