Cytochrome P450 2D6 (CYP2D6) is an enzyme that in humans is encoded by the CYP2D6 gene. CYP2D6 is primarily expressed in the liver. It is also highly expressed in areas of the central nervous system, including the substantia nigra.

Cytochrome P450 2D6 (CYP2D6) is a critical pharmacogene involved in the metabolism of ~20% of commonly used drugs across a broad spectrum of medical disciplines including psychiatry, pain management, oncology and cardiology. Nevertheless, CYP2D6 is ...

2021年10月15日 · One such member, CYP2D6 is involved in the metabolism of a wide range of medications including drugs for pain management, cancer, mental health disorders, some cardiovascular symptoms, chorea, and Gaucher disease (1, 2). This enzyme is encoded by the CYP2D6 gene, which is highly polymorphic.

2008年7月1日 · In this issue, we will discuss CYP2D6?an enzyme that is involved in the metabolism of numerous drugs. CYP2D6 also is involved in the activation of some drugs, so these drugs may have reduced efficacy when patients with inadequate CYP2D6 activity take them.

Cytochrome P450 CYP2D6 is the most extensively characterized polymorphic drug-metabolizing enzyme. A deficiency of the CYP2D6 enzyme is inherited as an autosomal recessive trait; these subjects (7% of Caucasians, about 1% of Orientals) are classified as poor metabolizers.

2020年10月28日 · CYP2D6 is a phase I drug-metabolizing enzyme involved in the biotransformation of 20%–25% of clinically prescribed drugs [107,108]. It is encoded by CYP2D6, which is located at 22q13.2 and is highly polymorphic with at least 137 star (*) alleles currently defined on PharmVar with multiple additional star allele subtypes also listed [109].

Cytochrome P450 family 2 subfamily D member 6 (CYP2D6) contributes to 2% and 0.7% of the overall hepatic and intestinal cytochrome P450 enzyme, respectively, and is estimated to be responsible for metabolism of 25% of commonly prescribed drugs (e.g., antidepressants, antipsychotics, opioids, beta blockers). Significant interpatient variability ...

2025年3月30日 · CYP2D6 (Cytochrome P450 Family 2 Subfamily D Member 6 (Gene/Pseudogene)) is a Protein Coding gene. Diseases associated with CYP2D6 include Drug Metabolism, Poor, Cyp2d6-Related and Warfarin Sensitivity. Among its related pathways are Clomipramine Pathway, Pharmacokinetics and Oxidation by cytochrome P450.

2024年4月7日 · The CYP2D6 gene is a critical component of drug metabolism and plays a significant role in the field of pharmacogenomics. This gene is responsible for breaking down medications like codeine and tricyclic antidepressants, …

2025年3月26日 · Its substrates include antidepressants, antipsychotics, analgesics and antitussives, beta adrenergic blocking agents, antiarrythmics and antiemetics. The gene is highly polymorphic in the human population; certain alleles result in the poor metabolizer phenotype, characterized by a decreased ability to metabolize the enzyme's substrates.