Cytochrome P450 family 2 subfamily C member 9 (abbreviated CYP2C9) is an enzyme protein. The enzyme is involved in the metabolism, by oxidation, of both xenobiotics, including drugs, and endogenous compounds, including fatty acids. In humans, the …

The CYP2C9 gene provides instructions for making an enzyme that is found in a cell structure called the endoplasmic reticulum, which is involved in protein processing and transport. The CYP2C9 enzyme breaks down (metabolizes) compounds including steroid hormones and …

CYP2C9 is an enzyme that is responsible for breaking down (metabolizing) several of the drugs that are commonly used today. Some medications, such as celecoxib, warfarin, and phenytoin require CYP2C9 in order for the medication to be metabolized to forms that are not active and are more easily eliminated from the body.

2008年3月1日 · In thisissue, we will discuss an old standby,CYP2C9, an enzyme involved in manyclinically important drug interactions. CYP450 enzymes, found primarily inthe liver, are involved in the metabolismof most medications; the mostimportant of these enzymes areCYP1A2, CYP2C9, CYP2C19, CYP2D6,and CYP3A4.

CYP2C9 is the enzyme responsible for the metabolism of the S-isomer of warfarin that is principally responsible for the anticoagulant effect of the drug. The crystal structure of human CYP2C9 was described by Williams et al. [46], for both CYP2C9 in complex with warfarin and unliganded CYP2C9 (Protein Data Bank ID: 1OG2 and 1OG5, respectively).

2017年12月28日 · CYP2C9 substrate selectivity is detailed and, based on crystal structures for the enzyme, we describe how CYP2C9 catalyzes these reactions. Factors relevant to clinical response to CYP2C9 substrates including inhibition, induction and genetic polymorphism are discussed in detail.

Gene ID: 1559, updated on 8-Feb-2025. This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of …

2025年3月3日 · The CYP2C9 gene provides instructions for creating an enzyme crucial for metabolizing various medications and substances. Variations in this gene can influence how effectively an individual processes certain drugs, leading to differences in drug response and potential side effects.

2018年8月15日 · CYP2C9. The cytochrome P450 2C9 (CYP2C9) is a member of the CYP2C subfamily of the cytochrome P450 enzymes and is the major metabolizing enzyme for S-warfarin and several other widely prescribed medications.

2025年3月30日 · CYP2C9 (Cytochrome P450 Family 2 Subfamily C Member 9) is a Protein Coding gene. Diseases associated with CYP2C9 include Coumarin Resistance and Warfarin Sensitivity. Among its related pathways are Metapathway biotransformation Phase I and II and Clomipramine Pathway, Pharmacokinetics.