Cytochrome P450 2A6 (abbreviated CYP2A6) is a member of the cytochrome P450 mixed-function oxidase system, which is involved in the metabolism of xenobiotics in the body. …

2025年3月30日 · This gene, CYP2A6, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions …

2012年5月5日 · The two most relevant substrates for CYP2A6 are coumarin and nicotine. Coumarin is the marker substance for determining CYP2A6 activity both in vitro and in vivo. …

This gene, CYP2A6, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in …

The cytochrome P450 2A6 (CYP2A6) enzyme metabolizes several clinically relevant substrates, including nicotine—the primary psychoactive component in cigarette smoke. The gene that …

This gene, CYP2A6, encodes a member of the Cytochrome P450 superfamily of Enzymes. The Cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in …

Studies with heterologously expressed CYP enzymes and human liver microsomes in vitro have revealed the key role of CYP2A6 in the catabolism of nicotine (Figure 1). In this two-step …

CYP2A6 is a key enzyme in nicotine inactivation pathway. Some subjects carry deficient CYP2A6 alleles, and they were shown to have a reduced risk and/or degree of smoking addiction …

加拿大多伦多大学 的科学家则发现，不同形态的cyp2a6基因能影响戒烟者对戒烟药品中尼古丁的吸收。 戒烟者对尼古丁代谢越慢，其血液中的尼古丁水平就越高，因而越发表现为烟瘾小 [2] 。

This gene, CYP2A6, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in …