CXCL12/CXCR7 chemotactic axis can promote the growth and proliferation of tumor cells, enhance the adhesion ability of tu-mor cells and promote the generation of tumor …
CXCR7 as a novel therapeutic target for advanced prostate cancer
2023年2月9日 · ACKR3 (Atypical Chemokine Receptor 3), traditionally called CXCR7, is up-regulated in many cancers, including advanced prostate cancer, and represents promising …
CXCR4 and CXCR7 Signaling Pathways: A Focus on the Cross …
The chemokine receptor 4 (CXCR4) and 7 (CXCR7) are G-protein-coupled receptors (GPCRs) activated through their shared ligand CXCL12 in multiple human cancers. They play a key role …
CXCR7 Targeting and Its Major Disease Relevance - PMC
In this review we focus on summarizing the endogenous and exogenous ligands of CXCR7, the main diseases related to CXCR7 and the biased signaling events happening on CXCR7. …
Frontiers | CXCR4 and CXCR7 Signaling Pathways: A Focus on the …
2021年4月14日 · In ovarian cancer, estrogen induces CXCR7 expression that promotes tumor cell migration, invasion and epithelial-mesenchymal transition (EMT) through CXCL11 while …
Molecular insights into intrinsic transducer-coupling bias in the …
2023年8月9日 · Here, we comprehensively characterize two chemokine receptors namely, CXCR4 and CXCR7, in terms of their transducer-coupling and downstream signaling upon …
Chemokine receptor CXCR7 activates Aurora Kinase A and …
2023年8月1日 · CXCR7 is an atypical chemokine receptor that recruits β-arrestin (ARRB2) and internalizes into clathrin-coated intracellular vesicles where the complex acts as a scaffold for …
肿瘤中的CXCL12-CXCR4/CXCR7轴：从机制到临床应用
2023年8月29日 · Sci.杂志上发表了题为“CXCL12-CXCR4/CXCR7 Axis in Cancer: from Mechanisms to Clinical Applications”的文章，该研究综述了肿瘤中的CXCL12-CXCR4/CXCR7 …
The atypical chemokine receptor ACKR3/CXCR7 is a broad
2020年6月19日 · Here we demonstrate that ACKR3/CXCR7, hitherto known as an atypical scavenger receptor for chemokines, is a broad-spectrum scavenger of opioid peptides. …
王淼课题组发现心血管药物新靶点: CXCR7可作为血管稳态与心梗 …
王淼教授课题组的研究发现cxcr7通过促进内皮细胞增殖与再生，调节血管稳态和心梗后心脏重构与功能（见图1），揭示cxcr7可作为防治介入术后血管再狭窄与心梗后心衰的新药物靶点。