The CXCR4 receptor upon binding its ligands triggers multiple signaling pathways that orchestrate cell migration, hematopoiesis and cell homing, and retention in the bone marrow. However, CXCR4 also directly controls cell proliferation of ...

有数据表明，前列腺癌表达的CXCR4水平比非恶性前列腺组织高35倍，这表明CXCR4表达可能是前列腺癌的诊断生物标志物。 CXCR4表达与淋巴结或骨转移显著相关。

2025年2月25日 · In this study, we present the high-resolution cryo-EM structure of a CXCR4 homo-tetramer, stabilized by both polar and nonpolar interactions between protomers, in the absence of a bound ligand or transducer proteins.

The chemokine receptor 4 (CXCR4) and 7 (CXCR7) are G-protein-coupled receptors (GPCRs) activated through their shared ligand CXCL12 in multiple human cancers. They play a key role in the tumor/tumor microenvironment (TME) promoting tumor ...

14 小时之前 · Inhibition of the CXCR4 receptor or the PLC pathway improved survival in Dex-treated NSG mice (NOD SCID gamma mice) and restored sensitivity in Dex-resistant B-ALL cell lines and patient-derived cells [19]. However, whether this improvement in GC sensitivity by inhibiting the CXCR4/PLC axis interferes with the mitochondrial pathway remains unclear.

2024年9月23日 · We show that CXCR4 adopts distinct subunit conformations in trimeric and tetrameric assemblies, highlighting how oligomerization could allosterically regulate chemokine receptor function.

2021年3月26日 · Here, we investigated whether CXCR4 regulates B cell viability by inducing hypoxia-inducible factor (HIF)-1α and nuclear factor (erythroid-derived 2)-like 2 (Nrf2) under a hypoxic condition in...

趋化因子受体 CXCR4 是 趋化因子 基质细胞衍生因子-1 （CXCL12）的特异受体 [1][2]。 CXCL12对 淋巴细胞 有强烈的趋化作用。 该受体是用来提取纯化 艾滋病毒 的几个趋化因子受体之一。 现在还不清楚是否出现使用CXCR4的人类免疫缺乏病毒是免疫缺乏的原因还是后果。

4 天之前 · In vitro experiments demonstrate that the CXCL12/CXCR4 axis drives the overactivation and cytotoxicity of CD8+T cells. In vivo treatment with a CXCR4 antagonist effectively reduces CD8+T cell accumulation in the heart, alleviates myocardial inflammation, and improves cardiac function in MC mice.

2016年9月1日 · Among the chemokine receptors, CXCR4 stands out for its pleiotropic roles in both physiological and pathological conditions and it represents a crucial target in drug development. In this review, we will focus on CXCR4 receptor signaling and its functional significance in health and disease.