CXCR3 is present in tumor and immune cells, and its two variants, CXCR3-A and CXCR3-B, have different molecular characteristics and can mediate biological effects with opposite results. Blocking CXCR3-A in tumor cells may be a novel anti-tumor strategy to prevent tumor cell invasion and metastasis.

Mar 10, 2011 · CXCR3 is a chemokine receptor that is highly expressed on effector T cells and plays an important role in T cell trafficking and function. CXCR3 is rapidly induced on naïve cells following activation and preferentially remains highly expressed on Th1-type CD4(+) T cells and effector CD8(+) T cells. …

Mar 30, 2025 · CXCR3 (C-X-C Motif Chemokine Receptor 3) is a Protein Coding gene. Diseases associated with CXCR3 include Cutaneous Lupus Erythematosus and Pulmonary Sarcoidosis . Among its related pathways are Class A/1 (Rhodopsin-like …

Jan 18, 2022 · CXCR3 is a chemokine receptor expressed by populations of antigen-experienced CD8+ T cells, including T MEM and T INT cells, and has been implicated in driving T cells into the splenic red pulp and toward an effector fate in settings of early acute infection and vaccination (Hu et al., 2011; Kohlmeier et al., 2011; Kurachi et al., 2011; Shah et ...

CXCR3 is a chemokine receptor that is rapidly induced on naïve T cells following activation, and preferentially remains highly expressed on type-1 helper (Th1)-type CD4+ T cells, effector CD8+ T cells and innate-type lymphocytes, such as natural ...

Jun 30, 2023 · Here, Moreno Ayala et al. show that CXCR3 expression on Treg cells puts them in close proximity to CXCL9-producing dendritic cells in tumors, where they suppress tumor antigen presentation and impede the antitumor CD8+ T cell response.

6 days ago · CXCR3 is a G protein-coupled receptor expressed on the cell surface of various cell types, including both immune cells and non-immune populations [].In immune cells such as T cells and dendritic ...

CXCR3 is a G protein-coupled, seven-transmembrane receptor that binds and is activated by the three IFN-gamma-inducible chemokines of the CXC family named CXCL9, CXCL10, and CXCL11. These chemokines are not constitutively expressed but are up-regulated in a proinflammatory cytokine milieu.

CXCR3 is a chemokine receptor that is highly expressed on effector T cells and plays an important role in T cell trafficking and function. CXCR3 is rapidly induced on naïve cells following activation and preferentially remains highly expressed on Th1 …

Sep 20, 2019 · CXCR3 is a highly expressed chemokine receptor that is activated by interferon-(IFN)-γ inducible ligands CXCL9, CXCL10 and CXCL11. CXCR3 is rapidly induced and expressed in activated CD8 effector T cells and CD4 T helper cells (Th1) and plays an essential role in the migration into lymphoid and peripheral tissues [ 7 , 8 ].