Chemokine receptor CXCR3 is a Gα i protein-coupled receptor in the CXC chemokine receptor family. Other names for CXCR3 are G protein-coupled receptor 9 (GPR9) and CD183. There are three isoforms of CXCR3 in humans: CXCR3-A, CXCR3-B and chemokine receptor 3-alternative (CXCR3-alt). [5]

趋化因子受体cxcr3是g蛋白偶连的七跨膜域受体，可选择性地与cxc趋化因子（cxcl9，cxcl10，和cxcl11）结合 [1] 。 cxcr3又称g蛋白偶联受体9(gpr9)和cd183。 CXCR3又称G蛋白偶联受体9(GPR9)和CD183。

cxcr3及其配体 cxcl9 、 cxcl10 和 cxcl11 与许多肿瘤的发展和进展密切相关。随着其作用机制的阐明，cxcr3有望成为评估肿瘤患者预后的新指标和临床肿瘤免疫治疗的新靶点。 cxcr3及其配体的组成和作用. 趋化因子受体cxcr3由三种 ifn-γ 诱导配体cxcl9、cxcl10和cxcl11激活诱导。

2025年3月30日 · CXCR3 (C-X-C Motif Chemokine Receptor 3) is a Protein Coding gene. Diseases associated with CXCR3 include Cutaneous Lupus Erythematosus and Pulmonary Sarcoidosis . Among its related pathways are Class A/1 (Rhodopsin-like receptors) and GPCR downstream signalling .

2023年3月26日 · cxcr3在将效应t细胞迁移到炎症和肿瘤部位中起着关键作用。cxcr3活化优先导致在th1型cd4+t淋巴细胞、效应cd8+t淋巴细胞，nk细胞和nkt细胞的高表达。cxcr3及其配体分布在不同的身体组织中，其表达可以调节不同免疫细胞的定向迁移。

2011年3月10日 · CXCR3 is a chemokine receptor that is highly expressed on effector T cells and plays an important role in T cell trafficking and function. CXCR3 is rapidly induced on naïve cells following activation and preferentially remains highly expressed on Th1-type CD4(+) T cells and effector CD8(+) T cells.

The CXC subgroup of chemokine receptors, CXCR3, is mainly expressed on the surface of activated T cells, B cells, and natural killer cells, and plays an essential role in infection, autoimmune diseases, and tumor immunity by binding to specific receptors on target cell membranes to induce targeted migration and immune responses.

3 天之前 · CXCR3 is a G protein-coupled receptor expressed on the cell surface of various cell types, including both immune cells and non-immune populations [].In immune cells such as T cells and dendritic ...

2022年1月18日 · CXCR3 is a chemokine receptor expressed by populations of antigen-experienced CD8+ T cells, including T MEM and T INT cells, and has been implicated in driving T cells into the splenic red pulp and toward an effector fate in settings of early acute infection and vaccination (Hu et al., 2011; Kohlmeier et al., 2011; Kurachi et al., 2011; Shah et ...

2025年3月28日 · CXCR3 and CXCR7 are chemokine receptors involved in cellular migration in physiological and pathophysiological context. Here, the authors present cryo-EM structures of CXCR3 in complex with small ...