Interleukin 8 (IL-8 or chemokine (C-X-C motif) ligand 8, CXCL8) is a chemokine produced by macrophages and other cell types such as epithelial cells, airway smooth muscle cells [3] and …

2025年3月30日 · CXCL8 (C-X-C Motif Chemokine Ligand 8) is a Protein Coding gene. Diseases associated with CXCL8 include Melanoma and Adult Respiratory Distress Syndrome. Among …

CXCL8 is the most potent human neutrophil-attracting chemokine and plays crucial roles in the response to infection and tissue injury. CXCL8 activity inherently depends on interaction with …

2023年5月18日 · Hematopoietic stem/progenitor cells from patients with MF are enriched for a CXCL8/CXCR2 gene signature and display enhanced proliferation and fitness in response to …

G-protein heterotrimer (alpha, beta, gamma subunits) constitutively binds to CXCR1/CXCR2 receptor and activation by IL8 leads to beta and gamma subunits release from Galpha (GNAI2 …

2022年3月14日 · In this review, we summarized the current understanding of CXCL8 signaling cascades and recently developed mechanisms of facilitating tumor survival, invasion, and …

2024年5月15日 · Among factors that facilitate neutrophil recruitment is the chemokine CXCL8, one of the most well-studied chemokines. In the JCI in 1989, Baggiolini and colleagues …

2021年12月27日 · In humans, Interleukin-8 (IL-8 or CXCL8) is a granulocytic chemokine with multiple roles within the tumor microenvironment (TME), such as recruiting …

In this review we provide a comprehensive overview of the CXCL8-CXCR1/2 axis and its role in the pathogenesis of various diseases including inflammation and cancer. CXCL8 is one of the …

Smith et al. (2005) identified a molecule produced by Schistosoma eggs, termed S. mansoni chemokine-binding protein (smCKBP), that bound several chemokines, including CXCL8. …