CTLA-4 - 百度百科
细胞毒T淋巴细胞相关 抗原 4（cytotoxic T lymphocyte-associated antigen-4, CTLA-4）又名CD152，是一种 白细胞分化抗原 ，是T细胞上的一种跨膜受体，与CD28共同享有B7分子配 …
Cytotoxic T-lymphocyte associated protein 4 - Wikipedia
Cytotoxic T-lymphocyte associated protein 4, (CTLA-4) also known as CD152 (cluster of differentiation 152), is a protein receptor that functions as an immune checkpoint and …
肿瘤免疫靶点 | CTLA-4 - 知乎 - 知乎专栏
ctla-4在控制t细胞活化和耐受性中起着至关重要的作用：总的来说一方面在调节性t细胞（treg）上介导其免疫抑制能力；另一方面在静息t细胞活化后表达ctla-4，作为反馈控制机制，通过调 …
Current Understanding of Cytotoxic T Lymphocyte Antigen-4 (CTLA-4 …
Cytotoxic T lymphocyte antigen-4 (CTLA-4) is an immune checkpoint molecule that is mainly expressed on activated T cells and regulatory T (Treg) cells that inhibits T-cell activation and …
CTLA-4的结构与功能：免疫抑制药物研发的基石 - 知乎
细胞毒T淋巴细胞相关抗原4（cytotoxic T lymphocyte-associated antigen-4, CTLA-4）又名CD152，是一种白细胞分化抗原。CTLA-4作为一类免疫检查点，参与免疫反应的负调节，对 …
CTLA-4 - 维基百科，自由的百科全书
CTLA4 又稱 CTLA-4 （細胞毒性T淋巴細胞相關抗原4，cytotoxic T-lymphocyte-associated protein 4）或 CD152 （分化群 152），是一种 蛋白质受体 [7]。 CTLA-4蛋白由小鼠的Ctla4 [8] 和人 …
聚焦药靶：一文尽览肿瘤免疫治疗分子CTLA-4的研究现状
2021年10月18日 · CTLA-4全名为细胞毒T淋巴细胞相关抗原4（Cytotoxic T Lymphocyte-Associated Antigen-4，CTLA-4）又名CD152，是由CTLA-4基因编码的T细胞表面跨膜蛋白， …
《协和医学杂志》：免疫检查点抑制剂CTLA-4在实体肿瘤治疗中的 …
2023年8月21日 · 近年来，针对细胞毒性 t 淋巴细胞相关蛋白4 (ctla-4)、程序性死亡[蛋白]-1 (pd-1)及其配体- 1（pd-l1）等免疫检查点相关抑制剂在肿瘤的免疫治疗方面取得了一定进展，开 …
Soluble CTLA-4 regulates immune homeostasis and promotes
Cytotoxic T-lymphocyte-associated antigen -4 (CTLA-4) is a co-inhibitory receptor that restricts T cell activation. CTLA-4 exists as membrane (mCTLA-4) and soluble (sCTLA-4) forms, but the …
CTLA-4: a moving target in immunotherapy - PMC - PubMed …
CTLA-4 is constitutively expressed in Treg or induced following T cell activation via CD28 and TCR signaling. In the absence of the ligand, CTLA-4 is mainly found in intracellular …