Fas/FasL - 百度百科
FasL是能够结合到死亡受体TNFRSF6/FAS的细胞因子，在T-cell发育中介导其由于细胞毒性引起的凋亡。Fas及其配体FasL是近年来研究得最为深入的有关细胞凋亡的膜表面分子，阐明它们在 …
人人学懂免疫学：第二十五期|免疫学|CTL|穿孔素|颗粒酶|靶细胞|杀 …
2021年8月2日 · CTL杀伤的第二种方法是：利用其表面的一种称为Fas配体（FasL）的蛋白质，与靶细胞表面的Fas蛋白结合，从而诱发靶细胞内的“自杀程序”，使靶细胞因凋亡而死亡。
Stored Fas Ligand, a Mediator of Rapid CTL-Mediated Killing, Has …
2009年12月27日 · Fas ligand (FasL), also known as CD178 or CD95L, is expressed on CTLs and functions by engaging the death receptor Fas (CD95) on target cells and triggering apoptosis. …
Cytotoxic T lymphocyte perforin and Fas ligand working in …
Two major cytotoxic T-lymphocyte (CTL) killing mechanisms: one fast-acting, perforin-mediated and one slower, Fas ligand (FasL) -based, account for most CTL activity in short-term in vitro …
CTLs Contain and Use Intracellular Stores of FasL Distinct from ...
2007年8月15日 · CTL lyse target cells through the release of cytolytic granule contents and cell surface expression of Fas ligand (FasL). Current models suggest that FasL is stored in …
Activated cytotoxic lymphocytes promote tumor progression by …
2014年4月28日 · We found that CTLs induced tumor cells to secrete PGE2 and increase tumor cell-mediated chemoattraction of MDSCs via Fas signaling, which was favorable to tumor …
Cytotoxic T lymphocyte perforin and Fas ligand working in ... - PubMed
We show that perforin expression among individual, conjugated CTL varies widely, which can account for the heterogeneity in killing speeds exhibited by individual CTL. Despite a 2-hr lag …
CTL 杀伤肿瘤细胞涉及具体机制 - dxy.cn
2024年11月21日 · CTL 攻击可通过半胱天冬酶非依赖性的方式切割核纤层蛋白（如核纤层蛋白 B）和核基质蛋白（如 NuMa），从而介导对细胞核的损伤，导致核膜破裂。 核膜破裂后，细 …
Signaling and transcriptional control of Fas ligand gene expression ...
2003年3月25日 · Fas ligand (FasL), a member of the tumor necrosis factor family, initiates apoptosis by binding to its surface receptor Fas. As a consequence, there is sequential …
CTL 杀伤实验 不懂操作步骤的同学看这里 - 丁香通研选
2015年7月9日 · CTL 杀伤靶细胞主要有两种途径：即细胞裂解性杀伤和诱导细胞凋亡 ( Apoptosis)。 前者指 CTL 分泌诸如穿孔素一类的介质损伤靶细胞膜； 后者指 CTL 通过表面 …