2025年3月30日 · CSF3R (Colony Stimulating Factor 3 Receptor) is a Protein Coding gene. Diseases associated with CSF3R include Neutrophilia, Hereditary and Neutropenia, Severe Congenital, 7, Autosomal Recessive. Among its related pathways are Akt Signaling and Signaling by CSF3 (G-CSF).

csf3是体内非常重要的细胞生长因子，通过与细胞表面特异性受体g-csfr（csf3r）结合，激活复杂的信号转导系统，发挥多种生物学功能，包括调节粒系的增殖、分化与存活，刺激粒细胞分泌血管内皮生长因子加强血管形成，动员骨髓干细胞至外周血以及诱导干细胞 ...

2024年3月20日 · 在单细胞分析过程中，想要对任何细胞类型进行进一步详细的亚群定义，都需要首先将目的细胞类型完整地从包含有各种其他细胞类型的混合群体中筛选出来，这个时候就需要我们对目的细胞类型的marker十分熟悉。 因此，为了能够更好地从各类细胞类型中筛选出 中性粒细胞，在此首先介绍几篇已发表的人的包含有中性粒细胞的单细胞数据来学习其中的用以定义中性粒细胞的marker。 1. COVID-19 immune features revealed by a large-scale single-cell …

2013年5月9日 · We identified activating mutations in the gene encoding the receptor for colony-stimulating factor 3 (CSF3R) in 16 of 27 patients (59%) with CNL or atypical CML.

Activating mutations in the granulocyte colony stimulating factor receptor (CSF3R), cooperate with loss of function mutations in the transcription factor CEBPA to promote acute myeloid leukemia development.

2025年3月28日 · CSF3R-AS is up-regulated and correlates with a poor prognosis in HCC. To explore the role of antisense circRNAs in the development of HCC, we performed circRNAs sequencing in three HCC tumor ...

2025年1月4日 · Clinical resource with information about CSF3R, Autosomal recessive severe congenital neutropenia due to CSF3R deficiency, Hereditary neutrophilia, and available tests. There are links to practice guidelines and authoritative resources like GeneReviews, PubMed, MedlinePlus, PharmGKB and clinicaltrials.gov.

2024年11月2日 · Title: [Analysis of CSF3R Gene Mutations and Clinical Characteristics in Patients with t(8;21) Acute Myeloid Leukemia]. Mutational screens highlight glycosylation as a modulator of colony-stimulating factor 3 receptor (CSF3R) activity.

2016年6月30日 · The CSF3R gene encodes the receptor for granulocyte colony-stimulating factor (CSF3; 138970), a 20- to 25-kD glycoprotein produced by macrophages stimulated with endotoxin, that plays an important role in granulopoiesis during the inflammatory process (summary by Fukunaga et al., 1990).

该基因的突变是导致科斯特曼综合征 (也称为严重先天性中性粒细胞减少症) 的原因。 [RefSeq 提供，2010 年 8 月] The protein encoded by this gene is the receptor for colony stimulating factor 3, a cytokine that controls the production, differentiation, and function of granulocytes.