2019年9月30日 · In this study, we identify a novel, critical function of CRT as a cell survival factor in multiple types of human solid-tissue malignancies. CRT knockdown activates p53, which mediates cell-death response independent of executioner caspase activity and accompanied full-length poly ADP ribose polymerase (PARP) cleavage.

27298-1-AP targets calreticulin in WB, IHC, IF/ICC, FC (Intra), ELISA applications and shows reactivity with human, mouse, rat samples. PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for …

钙网蛋白（Calreticulin，CRT） 肿瘤细胞在发生ICD的同时，CRT会暴露在细胞膜表面，做为一种“eat-me”信号，促进DC或其前体细胞吞噬已死或即将死亡的肿瘤细胞，从而提供丰富的抗原物质，促进DC细胞的成熟并行使其功能。

2016年11月4日 · In this study, we found that the IHC score for CRT (P < 0.01), age (P < 0.01), and postoperative chemotherapy or immunotherapy (P < 0.05) were independent prognostic factors (Table 1).

Plasma membrane CRT (also called ecto-CRT) serves as a co-stimulatory and pre-mortem (“eat-me”) signals to variety of immune cells but mainly to antigen presenting cells (APCs). Moreover, ecto-CRT is one of the main hallmarks of ICD in malignant diseases.

2023年3月16日 · A retrospective study using data from PBMCs of patients with non-operative EC that underwent chemoradiotherapy (CRT) showed that low density in Tregs and high concentration of double-positive (DP) CD4+ CD8+ T cells to be two independent predictive factors for response to CRT .

We studied the clinicopathological significance for Calreticulin (CRT) expression in pancreatic cancer (PC), and its functional relationship with other signaling genes (especially with p53) in regulating the biological behavior of PC cells. IHC, IF, IB, and real-time PCR were used to …

dc 细胞上能识别crt 的受体除lrp 外，可能还有清道夫受体、cd40 配体、trail或fas 配体等。所有这些配受体都可能与crt 相互作用，介导dc 细胞识别膜上表达crt 的细胞[25-26]。 2.5 钙网蛋白抗肿瘤免疫的机制. crt 介导抗肿瘤免疫的机制尚未完全阐明。

6 天之前 · l CRT membrane translocation in LLC cells, observed via confocal laser scanning microscopy. Scale bar = 50 μm. ... Immunohistochemistry (IHC) staining for CRT and HMGB1 was used to evaluate ICD ...

3 天之前 · E Immunohistochemical (IHC) staining of PRKCSH in rectal cancer tissues, comparing radiosensitive ... The neoadjuvant CRT regimen consisted of a total radiotherapy dose of 50 Gy, delivered in 2 Gy ...