The evolutionarily conserved cullin family proteins can assemble as many as 400 distinct E3 ubiquitin ligase complexes that regulate diverse cellular pathways. CUL4, one of three founding cullins conserved from yeast to humans, uses a large beta …

2015年12月15日 · Here, the work provides an overview to address the role of CRL4 E3 ubiquitin ligase in cancer development and progression, and discuss the possible mechanisms of CRL4 ligase involving in many cellular processes associated with tumor. Finally, we discuss its potential value in cancer therapy.

2022年12月19日 · 研究表明，IMiDs主要通过结合CRL4 E3泛素连接酶 (CRL4CRBN) 复合物的底物受体蛋白Cereblon (CRBN) 发挥其抗骨髓瘤活性。 通过结合CRBN，IMiDs改变了其底物的特性，导致骨髓瘤细胞存活所必需的蛋白质的泛素化和蛋白酶体降解。

Here, the work provides an overview to address the role of CRL4 E3 ubiquitin ligase in cancer development and progression, and discuss the possible mechanisms of CRL4 ligase involving in many cellular processes associated with tumor.

Based on evidence from knockout and transgenic mouse models, human clinical data, and biochemical interactions, we summarize the distinct roles of the CRL4 E3 ligase complexes in tumorigenesis, which appears to be tissue- and context-dependent.

2024年11月22日 · Our findings reveal that circRFWD2_369aa plays a crucial role in regulating the expression and ubiquitination of p27 in MM cells by forming complexes with DDB1 and CUL4A as an E3 ligase.

2022年9月16日 · It is now known that IMiDs exert their anti-myeloma activity mainly by binding cereblon (CRBN), the substrate receptor protein of the CRL4 E3 ubiquitin ligase (CRL4 CRBN) complex. By binding CRBN, IMiDs alter its substrate specificity, leading to ubiquitination and proteasomal degradation of proteins essential for MM cell survival.

CRL4 DCAF2 泛素连接酶是公认的细胞周期调节关键蛋白，在有丝分裂和S期过程中具有重要作用。 CRL4 DCAF2 可以促进复制起始蛋白（CDT1，SETD8）和细胞周期蛋白依赖激酶抑制剂p21发生 泛素化 降解。 但由于缺乏可行的动物模型，CRL4 DCAF2

In this article, we will discuss the genetic function, molecular assembly and substrates of CUL4– RING ligases (CRL4s). We will compare CUL4’s pleiotropic functions across several species, and review the current model for CUL4 assembly with its linker protein DDB1 (for damaged DNA binding) and its family of WD40 containing substrate receptors.

2015年8月18日 · We recently found that E3 ubiquitin ligase CRL4 is required for female fertility by regulating DNA hydroxymethylation to maintain oocyte survival and to promote zygotic genome reprogramming.