CAMP responsive element binding protein 1, also known as CREB-1, is a protein that in humans is encoded by the CREB1 gene. [5][6] This protein binds the cAMP response element, a DNA nucleotide sequence present in many viral and cellular promoters. The binding of CREB1 stimulates transcription.

Mar 30, 2025 · CREB1 (CAMP Responsive Element Binding Protein 1) is a Protein Coding gene. Diseases associated with CREB1 include Histiocytoma, Angiomatoid Fibrous and Melanoma Of Soft Tissue. Among its related pathways are Toll Like Receptor 7/8 (TLR7/8) Cascade and Calmodulin induced events.

cAMP反应元件 结合蛋白（cyclic-AMP response binding protein，CREB）由341个氨基酸残基构成，是富含 亮氨酸拉链结构 （bZIP）的超家族成员。 N端是富含酸性氨基酸的转录调节区，此区包括KID区（多种激酶诱导结构域）、X区（拮抗KID区的功能）、a区（增强CREB转录功能）、Q3区（刺激转录活性的关键部位）、Q2区（辅助转录作用）和PRO区（协助发挥转录作用）。 CREB活化的中心环节是Ser-133位点的磷酸化。

Creb1基因实现DNA结合转录激活剂活性、RNA聚合酶II特异性和 cAMP反应元件 结合活性。 Creb蛋白是Creb1基因转录翻译而来，通过可变剪切方式，形成多种剪接体：Crebα、Crebβ和Crebб等。

cAMP 反应元件 (cAMP response element, CRE) 是一段由30bp 左右的 DNA 片段构成的cAM P 应答序列, 这段序列含有高度保守的5′2 TGACGTCA 23′的8 碱基 回文结构, 其主要存在于基因的 启动子 与 增强子 上, 如即刻 早期基因 ( IEGs)cfo s、cjun 均有CRE 顺式作用元件。 CREB 作为一种选择性结合CREs 的 核蛋白, 表观分子量43000, 它的存在能刺激 基因转录, 所以, 又被称为转录 增强因子。 CREB、 环磷酸腺苷 反应元件 调节因子 (CREM ) 与转录活化因子1 (A TF2) 均是属于 …

CREB1 contributes colorectal cancer cell plasticity by regulating lncRNA CCAT1 and NF-kappaB pathways. cAMP-response element binding protein mediates podocyte injury in diabetic nephropathy by targeting lncRNA DLX6-AS1. Polymorphisms of COMT and CREB1 are associated with treatment-resistant depression in a Chinese Han population.

环腺苷酸反应元件结合蛋白1 (Cyclic AMP-responsive element-binding protein 1，CREB1/CREB) ，是一种磷酸化依赖的转录因子，与 DNA cAMP 反应元件 (CRE) 结合后刺激转录，CRE是存在于许多病毒和细胞启动子中的序列。

Development of effective HIV-1 vaccines requires synergy between innate and adaptive immune cells. We show that induction of the transcription factor CREB1 and its target genes by the recombinant canarypox vector ALVAC+Alum augments immunogenicity in Non-human primates (NHPs) and predicts reduced HIV-1 acquisition in the RV144 trial.

该基因编码的转录因子是 DNA 结合蛋白亮氨酸拉链家族的成员。 这种蛋白质作为同型二聚体与 cAMP 反应元件 (八聚体回文) 结合。 该蛋白质被几种蛋白激酶磷酸化，并诱导基因转录以响应 cAMP 通路的激素刺激。 该基因的交替剪接导致编码不同亚型的几种转录变体。 [RefSeq 提供，2016 年 3 月] This gene encodes a transcription factor that is a member of the leucine zipper family of DNA binding proteins.

CREB1 refers to a gene that encodes a transcription factor known as CREB. It is a basic leucine zipper (bZIP) transcription factor that plays various roles in cellular functions, including cell survival.