1999年12月17日 · CREB appears to mediate NGF-dependent neuronal survival and expression of Bcl-2. We tested whether Bcl-2 would overcome the proapoptotic effects of inhibition of CREB-dependent gene expression in sympathetic neurons.

2008年1月13日 · Here, we show that axons of developing mammalian neurons contain mRNA encoding the cAMP-responsive element (CRE)-binding protein (CREB). CREB is translated within axons in response to nerve...

2023年1月1日 · CCS improves neuronal function via inducing microglial M2 polarization. MG-derived NGF is the key mediator for MG-neuron symphony after CCS treatment. CCS increases MG-derived NGF level by CREB activation. Sg 3 (–1018 to –1011) is the key binding site for CREB-induced NGF transcription.

1997年11月1日 · BDNF-induced CREB phosphorylation and activation may regulate gene expression-dependent synaptic changes. In Aplysia californica, CREB has been shown to regulate synaptic plasticity in part by regulating genes that mediate changes in synaptic structure or the formation of new synaptic connections (4, 56).

CCS improved the neuronal synaptic plasticity and senescence by promoting MG-M2 activation driven by CREB-induced NGF upregulation and facilitated symphony communication between the microglia and neuron in AD. This study provides a new perspective on the development of a novel strategy for anti-AD t …

Nerve growth factor (NGF) is the prototypical member of the neurotrophin family of peptides, which includes brain-derived neurotrophic factor (BDNF), neurotrophin-3 (NT-3) and neurotrophin-4/5 (NT-4/5). Certain neurons survive a critical period during development, sustained by neurotrophins that are secreted by their innervation targets.

2001年8月1日 · Phosphorylation of CREB family members promotes target gene expression through the recruitment of the coactivator CREB-binding protein (CBP) and its paralogue p300.

1999年12月17日 · The transcription factor CREB is a critical mediator of NGF-dependent gene expression, but whether CREB family transcription factors regulate expression of genes that contribute to NGF-dependent survival of sympathetic neurons is unknown.

ccs 通过促进 creb 诱导的 ngf 上调驱动的 mg-m2 激活来改善神经元突触可塑性和衰老，并促进 ad 中小胶质细胞和神经元之间的交响通信。 该研究为抗AD治疗新策略的开发提供了新的视角，并为抗AD药物开发提供了新的靶点。

2010年10月29日 · CREB can be organized into distinct domains that allow it to dimerize, interact with DNA, cofactors, and the basal transcriptional complex. Located at the C-terminus of CREB is the bZIP DNA-binding domain, which binds to the CRE, and the dimerization domain, which allows CREB to homo- and hetero-dimerize (Schumacher et al. 2000). Located at the ...