HSP90在不同的癌症中过度表达，它们被认为是结直肠癌（CRC）中的致癌基因。 这些伴侣有选择性地稳定和激活一组客户蛋白。 许多HSP90客户蛋白在癌症生物学中发挥作用，因为它们调节细胞的基本功能，如细胞周期、凋亡和增殖。 HSP90促进CRC的机制之一是通过抑制MDM2和chipe3泛素连接酶来稳定mut p53，而MDM2和chipe3泛素连接酶通常会降解mutp53。 当HSP90稳定时，mut p53突变导致P53的丢失，并构成功能突变的增加，促进癌症的进展。 HIF-1α 是一 …

2021年10月24日 · In this review, we discuss the functional role of HSPs in CRC progression and highlight the significance of HSPs as diagnostic and prognostic biomarkers and emerging anti-CRC therapies that target HSPs in CRC.

Heat shock proteins (HSP) have been found to be elevated in CRC patients and HSPB1, HSPA1A and HSPC1 has been shown to have some prognostic value. CRC, in common with all cancers, has important associated oncogene and tumor suppressor gene associations and we show how many of these interact directly with one or more of the HSP.

Here, we characterised the expression of two major HSP proteins (HSP27 and 72) by immunohistochemistry (IHC), the mutation status of TP53, KRAS and PIK3CA genes by direct sequencing and the activation status of AKT by IHC in a …

In this study, we aimed to assess the prognostic significance of the three main HSPs described in relation to CRC in the literature (HSP 27, 70, 110), evaluating the correlation of HSP expression with the survival of patients suffering from CRC, and to discover the eventual link of HSP status to traditional clinico-pathological variables like ...

2018年8月1日 · In the present study, we conducted a genome-scale co-expression analysis to reconstruct the HSP in colorectal cancer (CRC). Five key modules were detected through network clustering, and a detailed discussion of two modules containing respectively 18 and 13 over and down-regulated members of HSP was provided.

Microbial involvement in colorectal cancer (CRC) is now well established. Short Chain Fatty Acids (SCFA) is the main products of anaerobic microbial fermentation in the large intestine and affects colonic health. SCFA mainly produced as microbial …

2016年4月22日 · In colon cancers, HSP110 is abnormally abundant. We have recently showed that colorectal cancer (CRC) patients with microsatellite instability (MSI) had an improved response to chemotherapy because they harbor an HSP110 inactivating mutation (HSP110DE9).

Heat shock protein 27 (Hsp27) is one of the most studied members of Hsp family. It has attracted particular attention in CRC pathogenesis, since it is involved in fundamental cell functions for cell survival. Evidence show that Hsp27 plays important roles in CRC progression and metastasis.

Subsequent immunohistochemical analysis of 81 primary human CRC tissues demonstrated that the expression of Hsp70 and Hsp110 was highly correlated with the advanced clinical stages and positive lymph node involvement.