Targeting carnitine palmitoyl transferase 1A (CPT1A) induces ...
2024年3月7日 · Here, through metabolomics, transcriptomics, a lung epithelial-specific Cpt1a -knockout mouse model, and clinical analysis, we demonstrate that CPT1A, a key rate-limiting …
Cell Death & Disease：曹亚团队揭示CPT1A介导的脂肪酸氧化通过 …
2022年，中南大学湘雅医院等单位的相关研究人员在《Cell Death & Disease》（IF: 8.5）上发表了题为“CPT1A-mediated fatty acid oxidation promotes cell proliferation via nucleoside …
CPT1A-mediated Fat Oxidation, Mechanisms, and Therapeutic ... - PubMed
2020年2月1日 · This review focuses on CPT1A, the liver isoform that catalyzes the rate-limiting step of converting acyl-coenzyme As into acyl-carnitines, which can then cross membranes to …
线粒体长链脂肪酸氧化障碍：肉碱棕榈酰转移酶 I 缺乏症（CPT1A
2023年11月14日 · CPT I Deficiency肉碱棕榈酰转移酶 I 缺乏症（CPT1A 缺乏症）是一种遗传性代谢疾病，会阻止身体将某些脂肪（长链脂肪酸）转化为能量，特别是在没有食物的时期。
Carnitine palmitoyltransferase 1 facilitates fatty acid oxidation in a ...
2024年12月24日 · Liver-specific double knockout of Cpt1a and Cpt1b or Cpt2 eliminates the mitochondrial oxidation of non-esterified fatty acids. However, Cpt1a/Cpt1b double knockout …
CPT1A-mediated fatty acid oxidation promotes cell ... - Nature
2022年4月11日 · In the present study, we found that CPT1A is a determining factor for the abnormal activation of FAO in nasopharyngeal carcinoma (NPC) cells. CPT1A is highly …
CPT1A induction following epigenetic perturbation promotes …
2023年12月7日 · In this study, we show that the carnitine palmitoyltransferase 1A (CPT1A) protein levels impact the strength and duration of the IFN-I response stimulated by intracellular …
Mitochondrial CPT1A: Insights into structure, function, and basis …
2023年3月23日 · CPT1A is an appealing druggable target for cancer therapies since it is essential for the survival, proliferation, and drug resistance of cancer cells. It will help to lower the risk of …
CPT1A对糖尿病肾病肾间质纤维化的保护作用 - tmmu.edu.cn
肉碱棕榈酰转移酶1A (carnitine palmitoyl-transferase 1A, CPT1A)是脂肪酸β-氧化 (fatty acid β-oxidation, FAO)的关键限速酶之一，其生物学作用是将脂酰CoA载入线粒体内膜进行FAO。 …
肉碱棕榈酰转移酶 1A（CPT1A）基因 | MCE
CPT I 是肉毒碱依赖性线粒体内膜转运中的关键酶，其缺乏会导致脂肪酸 β-氧化速率降低。 已发现该基因编码不同亚型的可变剪接转录物变体。 [RefSeq 提供，2008 年 7 月]