COL5A2 Gene - GeneCards | CO5A2 Protein | CO5A2 Antibody
2025年3月28日 · COL5A2 (Collagen Type V Alpha 2 Chain) is a Protein Coding gene. Diseases associated with COL5A2 include Ehlers-Danlos Syndrome, Classic Type, 2 and Classic Ehlers-Danlos Syndrome. Among its related pathways are …
Collagen, type V, alpha 2 - Wikipedia
Collagen alpha-2 (V) chain is a protein that in humans is encoded by the COL5A2 gene. [5][6] This gene encodes an alpha chain for one of the low abundance fibrillar collagens. Fibrillar collagen molecules are trimers that can be composed of one or more types of alpha chains.
COL5A2 gene - MedlinePlus
The COL5A2 gene provides instructions for making a component of type V collagen. Collagens are a family of proteins that strengthen and support many tissues in the body, including skin, ligaments, bones, tendons, and muscles. A component of type V collagen called the pro-α2(V) chain is produced from the COL5A2 gene. Collagens begin as rope ...
Cell重磅：V型胶原蛋白调控心脏损伤修复新机制 - 知乎
该篇文章由组学起始， 通过转录组学和蛋白质组学分析心脏损伤不同时间点变化情况，找到关键调控因子胶原蛋白Col5a1（Col V），后续通过基因敲除和药物干预深入解析了Col V在调节疤痕大小中的生理作用，为后续临床治疗奠定了理论基础。 研究材料： 小鼠缺血性心脏损伤后3, 7, 14, 21和42天的心脏疤痕组织和非损伤心肌组织. 技术方法：转录组学，蛋白质组学，单细胞测序. 研究结果. 1. 组学分析发现心脏损伤后疤痕组织中的 胶原蛋白基因 被显著诱导. 为了明确心肌梗 …
V 型胶原α2 链（COL5A2）基因 | MCE - MCE-生物活性分子大师
Fibrillar collagen molecules are trimers that can be composed of one or more types of alpha chains. Type V collagen is found in tissues containing type I collagen and appears to regulate the assembly of heterotypic fibers composed of both type I and type V collagen.
COL5A2 collagen type V alpha 2 chain [ Homo sapiens (human) ]
2024年11月27日 · Title: COL5A2 as a potential clinical biomarker for gastric cancer and renal metastasis. COL5A1 is an unfavorable factor for tumorigenesis, clinicopathological outcomes, and prognosis, whereas COL5A2 is only a favorable factor …
High expression of COL5A2, a member of COL5 family, indicates …
2021年4月30日 · COL5A2 was most closely related to advanced GC among COL5 family members. High COL5A2 expression is associated with a poor prognosis, and may be a novel therapeutic target for GC.
COL5A2 collagen type V alpha 2 chain [ (human)] - National …
High expression of COL5A2, a member of COL5 family, indicates the poor survival and facilitates cell migration in gastric cancer. Rare functional genetic variants in COL7A1, COL6A5, COL1A2 and COL5A2 frequently occur in Chiari Malformation Type 1.
COL5A2 collagen type V alpha 2 chain - NIH Genetic Testing …
2024年5月5日 · Collagen type V alpha 2 promotes the development of gastric cancer via M2 macrophage polarization. High expression of COL5A2, a member of COL5 family, indicates the poor survival and facilitates cell migration in gastric cancer. Tan Y, Chen Q, Xing Y, Zhang C, Pan S, An W, Xu HTan Y, et al. Biosci Rep, 2021 Apr 30. PMID 33739392.
COL5A2 是一种预后相关生物标志物，基于转录组学和单细胞 RNA …
V 型胶原蛋白 2 (COL5A2) 在各种癌症中都会增加，但目前尚不清楚它如何促进 GC 的预后和免疫。 癌症基因组图谱 (TCGA) 和基因表达综合 (GEO) 数据集用于下载转录组分析 (TCGA-STAD; GSE84437)、单细胞 RNA 测序 (scRNA-seq) 数据 (GSE167297) 和临床信息。 分析COL5A2的表达及其与临床病理因素的关系。 我们进行生存分析和Cox回归分析来评估GC的预后和独立因素。 还进行了共表达分析。 为了确定潜在的机制，我们对差异表达基因（DEG）和功能富集进行 …