Collagen alpha-2 (I) chain is a protein that in humans is encoded by the COL1A2 gene. [5][6] This gene encodes one of the chains for type I collagen, the fibrillar collagen found in most connective tissues.

The COL1A2 gene provides instructions for making part of a large molecule called type I collagen. Collagens are a family of proteins that strengthen and support many tissues in the body, including cartilage, bone, tendon, skin, and the white part of the eye (the sclera).

2025年3月30日 · COL1A2 (Collagen Type I Alpha 2 Chain) is a Protein Coding gene. Diseases associated with COL1A2 include Osteogenesis Imperfecta, Type Iv and Osteogenesis Imperfecta, Type Iii. Among its related pathways are Collagen chain trimerization and Enhanced binding of GP1BA variant to VWF multimer:collagen.

2005年1月28日 · COL1A1/2 osteogenesis imperfecta (COL1A1/2 -OI) is characterized by fractures with minimal or absent trauma, variable dentinogenesis imperfecta (DI), and, in adult years, hearing loss.

2012年10月12日 · Symptoms associated with mutations in this gene, however, tend to be less severe than mutations in the gene for the alpha1 chain of type I collagen (COL1A1) reflecting the different role of alpha2 chains in matrix integrity.

2021年12月10日 · Type I collagen (Col1), a fibrillar collagen, is the most abundant protein in mammals. The basic functional unit of Col1 is a heterotrimer consisting of two α1 chains and one α2 chain that...

2008年4月1日 · The COL1A2 gene is 36.67 kb and is composed of 52 exons that encode a 5411 base mRNA and a protein of 1366 amino acids. See figure summarizing basal transcription for COL1A2.

Sequencing of the COL1A2 gene indicated a 9-bp deletion of nucleotides 3418 to 3426, corresponding to the deletion of codons 1003 to 1006 of the gene and 3 amino acids, gly-pro-pro, of the protein.

We subjected Col1a2-CreERT: R26R tdTomato mice to I/R injury and performed immunofluorescence staining of heart sections by using the Wnt4 antibody.

The COL1A2 gene encodes the pro-alpha2 chain of type I collagen whose triple helix comprises two alpha1 chains and one alpha2 chain. Type I collagen is found in most connective tissues being particularly abundant in the cornea, dermis, tendon, and bone tissues.