ČKD Tatra-T3 tram car in Prague. T3 was the most successful ČKD tram manufactured from 1960 to 1989; 13991 units were sold worldwide, as of 2015 they are still the most common trams in the world.

2014年4月13日 · Low T3 levels are the most common laboratory finding followed by subclinical hypothyroidism in CKD patients. Hyperthyroidism is usually not associated with CKD but has been known to accelerate it. One of the most important links between thyroid disorders and CKD is …

The prevalence of low T3 increases with increasing CKD stage, and serum T3 level is associated with severity of CKD. Moreover, we assembled a comprehensive panel of clinical data to explore the significance of low T3 syndrome with respect to energy metabolism, calcium-phosphorus metabolism, anemia, and inflammatory state.

Chronic kidney disease (CKD) is characterized by a low T3 syndrome which is now considered a part of an atypical nonthyroidal illness. CKD patients also have increased incidence of primary hypothyroidism and subclinical hypothyroidism.

2024年7月15日 · Based on the physiology of T3 in CKD, the most amount of T3 is synthesized from the prohormone T4 in peripheral tissues. This conversion is catalyzed by type 1 and type 2 5’-deiodinase enzymes. Many factors related to CKD can contribute to a lower conversion of T4 to T3 in kidneys and other peripheral organs.

Low T3 levels are the most common laboratory finding followed by subclinical hypothyroidism in CKD patients. Hyperthyroidism is usually not associated with CKD but has been known to accelerate it. One of the most important links between thyroid disorders and CKD is uremia.

慢性肾脏病(CKD)患者发生甲状腺功能减退(hypothyroidism)的风险增加，多数呈亚临床表现，以低T3综合征最为常见，表现为血浆游离三碘甲状腺素(FT3)和总三碘甲状腺素(TT3)水平降低，而反式三碘甲状腺素(rT3)、游离甲状腺素(T4)及促甲状腺素(TSH)水平通常正常。

In a large cohort of inpatients, the prevalence of low-T3 syndrome was 2.5 times higher in patients with advanced kidney disease, compared to those with normal kidney function. In advanced CKD, both eGFR and proteinuria were strongly correlated with thyroid hormones.

2016年11月18日 · Low T3 has been associated to different inflammation markers, endothelial activation, malnutrition, and cardiac dysfunction in CKD. All these conditions could alter iodothyronine deiodination interfering with the normal process of T3 synthesis from T4 (low FT3) and reduce protein synthesis decreasing serum total T3 concentrations (low TT3).

2016年4月8日 · The increasing prevalence of low T3 as CKD progresses indicates its value as a predictor of worsening CKD. Furthermore, low T3 syndrome is closely associated with both malnutrition-inflammation complex syndrome (MICS) and anemia.