Classically, clear cell renal cell carcinoma (CK7-) from other renal cell carcinoma subtypes (including papillary, chromophobe and clear cell papillary); however, CK7 immunoreactivity in clear cell renal cell carcinomas can be variable with low grade clear cell RCC, multicystic renal neoplasm of low malignant potential and clear cell papillary ...

The CK7+/CK20− phenotype, the most frequent (~60%) adenocarcinomas of unknown origin, has been chosen to introduce new molecular biology techniques that can complement IHC in cases of undifferentiated or non-specific forms of CUPs [65,66].

Immunohistochemistry (IHC) is a test pathologists perform to see CK7-producing cells in a tissue sample. When combined with other immunohistochemical markers, this test allows pathologists to determine if the cells they are seeing under the microscope come from one of the organ systems that normally produces this protein.

CK7. 几乎 100% 的肺腺癌均表达 CK7，但 CK7 的特异性较低，30%-60% 的肺鳞癌阳性； CK7 也表达于乳腺、胃、卵巢、子宫等部位的腺癌，需与 TTF-1、NapsinA 联合应用。 02. 鳞癌. P63. 超过 90% 的肺鳞癌细胞核强阳性，但有 10%-33% 的肺腺癌呈局灶性低水平表达 P63。

Relative expression of CK20/CK7 is an approved diagnostic tool to help determine site of origin in metastatic carcinomas. CK20 is specific for colonic, urothelial and Merckel cell carcinoma. On the other hand, CK7 is characteristic of glandular malignancies originating from breast, respiratory tract, biliary tract and Mullarian epithelium.

As the CK7 antigen is found in both healthy and neoplastic cells, antibodies against CK7 together with CK20 can be used for immunohistochemistry (IHC) staining to determine the origin of the tumor. Most CRCs show positive IHC staining for CK20 and negative staining for CK7.

2022年6月1日 · Combined analysis of cytokeratin 7 (CK7) and cytokeratin 20 (CK20) is often used for assessing the origin of metastatic cancer. To evaluate the diagnostic utility of CK7 and CK20, tissue microarrays containing 15,424 samples from 120 different tumor types and subtypes and 608 samples of 76 different normal tissue types were analyzed by ...

Clones RN7 and OV-TL 12/30 react with the human cytokeratin intermediate filament protein (54 kD) identified as cytokeratin 7. Cytokeratin 7 is recommended for the detection of specific antigens of interest in normal and neoplastic tissues, as an adjunct to conventional histopathology using non-immunologic histochemical stains.

在肝细胞、胆管及肝细胞肝癌（HCC）、肝内胆管癌（ICC）和转移性癌中几乎 100% 表达。 CK19/CK7. 常被称为 胆管型细胞角蛋白，表达于 ICC，而在 HCC 中不表达，可用于 HCC 和 ICC 的鉴别。 其在转移性腺癌中也有表达。 HepPar-1. 存在于正常人肝细胞和大多数的肝细胞癌中，绝大多数的肝细胞癌为阳性表达，与其它肿瘤包括消化道肿瘤细胞没有交叉反应。 甲胎蛋白 （AFP） AFP 在正常肝组织及肝脏良性病变中不表达，在肝脏转移癌中几乎不表达。 其表达率 …

2024年12月2日 · Many algorithmic approaches using immunohistochemical (IHC) profile have been proposed for carcinomas of unknown primary, and they almost always include the coordinate expressions of CK7 and CK20 2–10. However, with the increased availability of newer and more specific biomarkers and molecular techniques, it is timely to revisit the utility ...