Combined analysis of cytokeratin 7 (CK7) and cytokeratin 20 (CK20) is often used for assessing the origin of metastatic cancer. To evaluate the diagnostic utility of CK7 and CK20, tissue microarrays containing 15,424 samples from 120 different tumor types and subtypes and 608 samples of 76 different …

The CK7+/CK20− pattern was observed for 95% of metastatic lesions biopsied in patients with primary lung cancer. One sample obtained from the rib, in a patient with a lung mass, stained negative for both cytokeratin 7 and 20. The primary lung tumour from this patient showed strong staining with CK7, and was negative for CK20.

Breast carcinoma is usually CK7+ / CK20-, cervical adenocarcinoma is usually CK7+ / CK20-, gastric carcinoma can be either CK7+ / CK20- (majority) or CK7+ / CK20+ and primary ovarian mucinous carcinoma is either CK7+ / CK20+ or CK7+ / CK20 variable (although lower GI type mucinous tumors arising in teratoma can be CK7-).

We studied the expression of cytokeratin (CK)-7 and CK-20 in prostate adenocarcinoma and urothelial carcinoma and evaluated their usefulness for distinguishing high-grade forms of these tumors. We examined prostate adenocarcinoma in 59 radical prostatectomy specimens and in 10 autopsy specimens show …

2011年3月15日 · Cytokeratin 7 (CK7) and cytokeratin 20 (CK20) are low molecular weight cytokeratins. The expressions of CK7 and CK20 have been studied in various primary and metastatic carcinomas. Their expression patterns may help to distinguish the site of origin of metastatic carcinomas.

2000年9月1日 · Cytokeratin 7 (CK 7) and cytokeratin 20 (CK 20) are low molecular weight cytokeratins. Their anatomic distribution is generally restricted to epithelia and their neoplasms. We surveyed...

In the present CRC tumours showed increased percentage of CK 20 negativity and reduced percentage CK7 positivity. The reason for this discrepancy could be explained by difference in the studied population, technical variations in immunohistochemical …

CK7 and CK20 are the most useful cytokeratins to diagnose and differentiate carcinomas. The co-expression of CK7 and CK20 is examined in different carcinomas (8 - 10). Recently, researches have focused on detecting the origin of metastatic carcinomas, using the CK7 and CK20 (11 - 13).

2000年9月1日 · Cytokeratin 7 (CK 7) and cytokeratin 20 (CK 20) are low molecular weight cytokeratins. Their anatomic distribution is generally restricted to epithelia and their neoplasms. We surveyed 435 epithelial neoplasms from various organ systems by immunohistochemistry using CK 7 and CK 20 monoclonal antibodies.

2004年2月13日 · On the basis of the heterogeneity of cytokeratins 7 and 20 expression in malignant epithelial tumors, the cytokeratin 7/20 immunophenotype has served as a useful diagnostic tool for...