Protein CIP2A also known as cancerous inhibitor of PP2A (CIP2A) is a protein that in humans is encoded by the KIAA1524 gene. [5][6] CIP2A is a regulatory protein involved in the inhibition …

2025年3月28日 · CIP2A (Cellular Inhibitor Of PP2A) is a Protein Coding gene. Diseases associated with CIP2A include Prostate Cancer and Gastric Cancer. Among its related …

2022年7月16日 · Here, we identify CIP2A as a TOPBP1-interacting protein that regulates TOPBP1 localization specifically in mitosis. Cells lacking CIP2A display increased radio …

蛋白磷酸酶2A癌性抑制因子(cancerous inhibitor of protein phosphatase 2A, CIP2A)是蛋白磷酸酶2A (protein phosphatase 2A, PP2A)的内源性抑制剂，它主要通过抑制PP2A使Akt去磷酸化并稳 …

2024年1月1日 · CIP2A (cancerous inhibitor of PP2A) coordinately controls the essential characteristics of cancer cells such as protein phosphorylation, mitosis, and the DNA damage …

2024年2月6日 · Here, we reported that oncoprotein cancerous inhibitor of protein phosphatase 2A (CIP2A) inhibited glycolysis and promoted oxidative metabolism in NSCLC cells. CIP2A bound …

CIP2A inactivates protein phosphatase 2A (PP2A) which down-regulates Akt (Protein Kinase B) phosphorylation and stabilizes c-Myc (c-Myc oncogene product) in cancer cells. CIP2A has …

2023年2月28日 · Here, we report molecular level details and structural mechanisms of PP2A-B56α inhibition by an oncoprotein CIP2A. Upon direct binding to PP2A-B56α trimer, CIP2A …

Protein phosphatase 2A (PP2A) is a critical human tumor suppressor. Cancerous inhibitor of PP2A (CIP2A) supports the activity of several critical cancer drivers (Akt, MYC, E2F1) and …

蛋白磷酸酶2A的癌性抑制因子 (CIP2A)近来被鉴定与多种恶性肿瘤的发生和发展密切相关.研究表明CIP2A可以通过稳定c-Myc、促进细胞增殖和锚定独立生长、阻滞衰老和分化来促进体内恶性 …