mpr有两种类型（cd-mpr和ci-mpr），共同参与溶酶体蛋白的运输过程。 也有些蛋白通过非M6P-MPR依赖的途径靶向到溶酶体。 例如溶酶体整合膜蛋白（ LIMP-II ）负责运输溶酶体β-葡萄糖脑苷脂酶（β-GC）， Sortilin 可以转运神经降压素（NT），脂蛋白脂肪酶和鞘脂激活 ...

The CI-MPR and CD-MPR are structurally distinct receptors however they share an overall general structure as they are both type I integral membrane proteins. Both receptors have a large N-terminal extracytoplasmic domain, one transmembrane …

2024年1月1日 · The cation-independent mannose 6-phosphate receptor (CI-M6PR) is a ubiquitous transmembrane receptor whose main intracellular role is to direct enzymes carrying mannose 6-phosphate moieties to lysosomal compartments. Recently, the small membrane-bound portion of this receptor has appeared to be implicated in …

研究人员报告称，溶酶体靶向嵌合体（LYTACs）是一种双功能分子，有两个结合域（下图），一端携带与细胞表面跨膜受体CI-M6PR（cation-independent mannose-6-phosphate receptor）结合的低聚糖肽（oligoglycopeptide）基团，另一端携带一个与靶蛋白结合的抗体或小分子。

2009年12月11日 · The 300-kDa cation-independent mannose 6-phosphate receptor (CI-MPR), which contains multiple mannose 6-phosphate (Man-6-P) binding sites that map to domains 3, 5, and 9 within its 15-domain extracytoplasmic region, functions as an efficient carrier of Man-6-P-containing lysosomal enzymes.

阳离子-非依赖甘露糖-6-磷酸受体（cation-independent mannose-6-phosphate receptor，CI-M6PR，又称IGF2R）是LTR的典型代表，能够将含有甘露糖-6-磷酸（mannose 6-phosphate，M6P）支链的N糖原修饰的蛋白质转运到溶酶体进行降解【2】。

阳离子非依赖性甘露糖 6-磷酸受体 (ci-m6pr) 是一种普遍存在的跨膜受体，其主要细胞内作用是将携带甘露糖 6-磷酸部分的酶引导至溶酶体区室。 最近，该受体的小膜结合部分似乎与许多病理生理过程有关。

2020年9月9日 · Clinically, endogenous CI-MPR delivers infused recombinant enzymes to lysosomes in the treatment of lysosomal storage diseases. Although four of the 15 domains comprising CI-MPR’s extracellular...

The multifunctional 300 kDa mannose 6-phosphate receptor (MPR300/CI-MPR) is a type I transmembrane glycoprotein that contains two distinct M6P binding sites in repeating segments 3 and 9 and a single IGF II binding site in repeat 11.

In this report, we describe the endocytic trafficking and steady-state localization of a chimeric form of the CI-MPR containing the ecto-domain of the bovine CI-MPR and the murine transmembrane and cytoplasmic domains expressed in a CHO cell line.