Neuronal acetylcholine receptor subunit alpha-4, also known as nAChRα4, is a protein that in humans is encoded by the CHRNA4 gene. [5] [6] The protein encoded by this gene is a …

2025年3月30日 · CHRNA4 (Cholinergic Receptor Nicotinic Alpha 4 Subunit) is a Protein Coding gene. Diseases associated with CHRNA4 include Epilepsy, Nocturnal Frontal Lobe, 1 and …

2023年12月7日 · 王丽蕊团队发现CHRNA4能够特异性表达在肝实质细胞中，并且在MASH小鼠和患者的肝脏中显著上升，与MASH严重程度正相关。 此外，研究人员发现CHRNA4内源性配 …

该基因编码烟碱型乙酰胆碱受体，属于配体门控离子通道超家族，在突触的快速信号传输中发挥作用。 这些五聚体受体可以结合乙酰胆碱，从而引起构象的广泛变化，从而导致跨质膜的离子 …

2025年3月26日 · Title: Autosomal dominant sleep-related hypermotor epilepsy caused by a previously unreported CHRNA4 variant. Sleep-related hypermotor epilepsy associated …

The CHRNA4 gene provides instructions for making one part (subunit) of a larger protein called a neuronal nicotinic acetylcholine receptor (nAChR). Learn about this gene and related health …

The genes coding for phosphoenolpyruvate carboxykinase-1 (PCK1) and neuronal nicotinic acetylcholine receptor alpha-4 subunit (CHRNA4) map to human chromosome 20, extending …

2024年12月10日 · These pentameric receptors can bind acetylcholine, which causes an extensive change in conformation that leads to the opening of an ion-conducting channel across the …

2024年8月28日 · The α4β2 nAChRs are crucial ion channels that control neurotransmitter release and play a role in various physiologic and pathologic processes. CHRNA4 encodes the α4 …

2025年2月8日 · these results provide evidence for a change in neural impulse activity received by skeletal muscles associated with a knock-in mutation in CHRNA4 expressed in the brain. …