CEBPA - Wikipedia
In addition, CEBPA is essential for myeloid lineage commitment and therefore required both for normal mature granulocyte formation and for the development of abnormal acute myeloid …
CEBPA Gene - GeneCards | CEBPA Protein | CEBPA Antibody
2025年3月30日 · CEBPA is an intronless gene that is required for granulocyte formation in mice. N-terminal nonsense mutations result in a dominant negative C/EBP-alpha protein while C …
CEBPA gene - MedlinePlus
The CEBPA gene provides instructions for making a protein called CCAAT enhancer-binding protein alpha. This protein is a transcription factor, which means that it attaches (binds) to …
Acute Myeloid Leukemia With CEBPA Mutations: Current Progress …
2022年2月22日 · Mutations in CCAAT enhancer binding protein A gene (CEBPA) are one of the common genetic alterations in acute myeloid leukemia (AML). Recently, the emergence of …
Prognostic impact of CEBPA mutational subgroups in adult AML
2024年1月16日 · Mutations of the gene encoding the CCAAT-enhancer binding protein alpha (CEBPA) transcription factor are common genetic alterations in acute myeloid leukemia (AML). …
CEBPA CCAAT enhancer binding protein alpha [ (human)]
Long noncoding RNA CEBPA-DT promotes cisplatin chemo-resistance through CEBPA/BCL2 mediated apoptosis in oral squamous cellular cancer. Targeting cancer cell plasticity by HDAC …
CEBPA phase separation links transcriptional activity and 3D …
2023年8月29日 · Here we present evidence that the lineage-instructive TF CEBPA drives extensive chromatin compartment switching and promotes the formation of long-range …
Expression and regulation of C/EBPα in normal myelopoiesis and …
2017年4月13日 · In this review, we emphasize the importance of C/EBPα for neutrophil maturation, its role in myeloid priming of hematopoietic stem and progenitor cells, and its …
The CEBPA gene provides instructions for making a protein called CCAAT enhancer-binding protein alpha. This protein is a transcription factor, which means that it attaches ( binds) to …
CEBPA restricts alveolar type 2 cell plasticity during ... - Nature
2024年5月16日 · We show that AT2 cells use a cell-type-specific transcription factor (TF) CEBPA to restrict their plasticity at neonatal and mature stages, but reactivate the developmental …
C/EBPɑ is crucial determinant of epithelial maintenance by
2020年2月7日 · We identified C/EBPα as one of the most TGF-β-mediated downregulated transcription factors in human mammary epithelial cells. C/EBPα expression prevents TGF-β …
CEBPA- Associated Familial Acute Myeloid Leukemia (AML)
2010年10月21日 · CEBPA-associated familial acute myeloid leukemia (AML) is defined as the presence of a heterozygous germline CEBPA pathogenic variant in an individual with AML …
CEBPA - My Cancer Genome
CCAAT/enhancer binding protein, alpha (CEBPA) is a gene that encodes a protein that functions as a transcription factor that contains a leucine zipper and identifies CCAAT motifs in the …
CEBPA-Associated Familial Acute Myeloid Leukemia (PDQ®)
2023年12月14日 · CEBPA-Associated Familial AML is a hereditary hematologic malignancy syndrome associated with the CEBPA gene. Learn about CEBPA-associated familial AML's …
The regulatory control of Cebpa enhancers and silencers in the
2019年6月10日 · Cebpa(7) is the strongest enhancer in uninduced conditions, upregulating activity ∼6-fold relative to Cebpa(0). Cebpa(7)’s enhancing effect is moderated somewhat to 3 …
Expression and regulation of C/EBPα in normal myelopoiesis and …
2017年4月13日 · We discuss that mutations in the open reading frame of CEBPA lead to an altered C/EBPα function, affecting the expression of downstream genes and consequently …
Tumor suppressor CEBPA interacts with and inhibits DNMT3A …
2022年1月26日 · Here, we show that CCAAT/enhancer binding protein α (CEBPA) interacts with the long splice isoform DNMT3A, but not the short isoform DNMT3A2. CEBPA, by interacting …
Targeting C/EBPα overcomes primary resistance and improves
2023年4月5日 · These findings highlight C/EBPα activation as a targetable PR mechanism and support clinical studies aimed at testing the combination of guanfacine with FLT3i in …
Acute Myeloid Leukemia With CEBPA Mutations: Current Progress …
2022年2月1日 · Mutations in CCAAT enhancer binding protein A gene (CEBPA) are one of the common genetic alterations in acute myeloid leukemia (AML). Recently, the emergence of …
Mutation of CEBPA in Familial Acute Myeloid Leukemia
2004年12月2日 · We describe a family in whom three members affected by acute myeloid leukemia (AML) had an identical, 212delC mutation in CEBPA, the gene encoding the …