Carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein) (CEACAM1) also known as CD66a (Cluster of Differentiation 66a), is a human glycoprotein, and a member of the carcinoembryonic antigen (CEA) gene family.

The type I membrane protein receptor carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) distinctively exhibits significant alternative splicing that allows for tunable functions upon homophilic binding.

2025年3月30日 · CEACAM1 (CEA Cell Adhesion Molecule 1) is a Protein Coding gene. Diseases associated with CEACAM1 include Adenomatoid Tumor and Colorectal Cancer. Among its related pathways are Innate Immune System and MITF-M-dependent gene expression. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity.

Due to its multi-faceted role as a recently appreciated immune checkpoint inhibitor and tumor marker, CEACAM1 is an attractive target for cancer immunotherapy. Herein, we highlight CEACAM1's function in various immune compartments and cancer types, including in the context of metastatic disease.

2018年7月2日 · Here we show using lymphocytic choriomeningitis virus (LCMV) infection that carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) is fundamental for recruiting...

2006年6月1日 · CEACAM1 functions as a MHC-class-I-independent inhibitory receptor on natural killer cells when ligated homophilically by CEACAM1 on target cells, such that overexpression of CEACAM1...

CEACAM1 plays a pivotal role in vascular homeostasis, particularly influencing the formation, maturation, and aging of blood vessels, as well as the endothelial barrier function. It supports endothelium‐dependent vasodilation and nitric oxide formation, thus promoting vascular integrity and regulating blood pressure.

2025年2月8日 · Human CEACAM1 is targeted by a Streptococcus pyogenes adhesin implicated in puerperal sepsis pathogenesis. CEACAM1 Is a Prognostic Biomarker and Correlated with Immune Cell Infiltration in Clear Cell Renal Cell Carcinoma.

2016年9月30日 · CEACAM1 is an essential downstream effector of VEGF because VEGF-induced angiogenesis is greatly reduced in vitro in endothelial cells following siRNA-mediated CEACAM1-knockdown and in vivo in CEACAM1 −/− mice (Kilic et al. 2005; Gu et al. 2009).

The type I membrane protein receptor carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) distinctively exhibits significant alternative splicing that allows for tunable functions upon homophilic binding.