Cyclin-dependent kinase 8 - Wikipedia
Cell division protein kinase 8 is an enzyme that in humans is encoded by the CDK8 gene. [5][6] The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) …
CDK8 Gene - GeneCards | CDK8 Protein | CDK8 Antibody
2024年12月24日 · CDK8 (Cyclin Dependent Kinase 8) is a Protein Coding gene. Diseases associated with CDK8 include Intellectual Developmental Disorder With Hypotonia And …
CDK8 cyclin dependent kinase 8 [ (human)] - National Center for ...
Cyclin dependent kinase 8 (CDK8) is essential for survival of BCR-ABL1p185+ leukemic cells. Compared with adjacent normal tissues, pancreatic cancer tissues showed upregulation of …
CDK8 is a positive regulator of transcriptional elongation
2010年1月24日 · Here we show, using a human tumor cell line, that CDK8 is a positive regulator of genes within the serum response network, including several members of the activator …
The human CDK8 subcomplex is a molecular switch that controls …
The human CDK8 subcomplex (CDK8, cyclin C, Med12, and Med13) negatively regulates transcription in ways not completely defined; past studies suggested CDK8 kinase activity was …
Cell：扼住肿瘤生长的咽喉--CDK8可能成为肿瘤治疗靶点-MedSci.cn
The Mediator-associated kinase CDK8, but not the paralog CDK19, is required for induction of many HIF1A target genes. HIF1A induces binding of CDK8-Mediator and the super elongation …
Transcriptome-based chemical screens identify CDK8 as a ... - Cell …
2023年6月27日 · Using a high-throughput transcriptional sequencing method (DRUG-seq2), we found that the cyclin-dependent kinase 8 inhibitor (CDK8i) MSC2530818 (MSC) plus A-83-01 …
细胞周期蛋白依赖性激酶 8（CDK8）基因 | MCE
该基因编码细胞周期蛋白依赖性蛋白激酶 (CDK) 家族的成员。 已知 CDK 家族成员是细胞周期进程的重要调节因子。 这种激酶及其调节亚基细胞周期蛋白 C 是 Mediator 转录调节复合物的组 …
Cell：CDK8基因不仅是癌症催生剂，还是“能量”管家！
2017年11月8日 · 该研究对应论文则发表在最新上线的Cell Reports杂志，名为CDK8 Kinase Activity Promotes Glycolysis。 CDK8基因的关键角色. 先前的研究表明，CDK8基因的过度表达 …
Molecular and in vivo Functions of the CDK8 and CDK19 Kinase Modules
2019年1月14日 · CDK8 and its paralog, CDK19, collectively termed 'Mediator Kinase,' are cyclin-dependent kinases that have been implicated as key rheostats in cellular homeostasis and …