CDK4/6 initiates Rb inactivation and CDK2 activity coordinates cell ...
2022年10月7日 · Our data show that CDK4/6 activation induces Rb inactivation and thereby E2F activation, driving a gradual increase in CDK2 activity. We found that rapid CDK4/6 inhibition …
细胞周期调控 - 知乎 - 知乎专栏
Cyclin E-CDK2负责完成RB1的磷酸化，通过释放更多的E2F，促进细胞进入S期所需的蛋白质的合成。 在G1期的发展过程中，一些E2F转录生成的蛋白在DNA复制起点聚集并形成 复制前复合 …
Rapid adaptation to CDK2 inhibition exposes intrinsic cell-cycle ...
2023年6月8日 · CDK4/6 activity backstops inhibition of CDK2 and sustains the proliferative program by maintaining Rb1 hyperphosphorylation, active E2F transcription, and cyclin A2 …
Concurrent inhibition of CDK2 adds to the anti-tumour activity
Therapeutic co-targeting of CDK2 and CDK4/6 is synergistic in GIST cell lines with intact RB1, through inhibition of RB1 hyperphosphorylation and cell proliferation. Moreover, RB1 …
Cell cycle and beyond: Exploiting new RB1 controlled mechanisms …
Canonically, RB1 regulates cell cycle progression and represents the down-stream target for CDK4/6 inhibitors that are in clinical use. However, newly discovered features of the RB1 …
Cdk2 strengthens the intra-S checkpoint and counteracts cell
2017年10月18日 · Cyclin-dependent kinase 2 (Cdk2) is a key cell cycle regulator, with roles in inactivating phosphorylation of the RB1 (pRb) tumour suppressor family and in controlling...
Concurrent inhibition of CDK2 adds to the anti-tumour activity
2022年9月29日 · We identify recurrent genomic aberrations in cell cycle regulators causing co-activation of the CDK2 and CDK4/6 pathways in clinical GIST samples. Therapeutic co …
TFIIH kinase CDK7 drives cell proliferation through a common core ...
2025年2月28日 · As the CDK (cyclin-dependent kinase) activating kinase (CAK), CDK7 phosphorylates and activates CDK4/6, CDK1, and CDK2, which act in the nucleus and …
Concurrent inhibition of CDK2 adds to the anti-tumour activity of …
2022年11月11日 · We identify recurrent genomic aberrations in cell cycle regulators causing co-activation of the CDK2 and CDK4/6 pathways in clinical GIST samples. Therapeutic co …
Targeting CDK2 to circumvent treatment resistance in HR
2024年12月27日 · To obtain mechanistic insights into this observation, the authors checked the ability of the CDK4/6 inhibitor abemaciclib to limit RB1 phosphorylation in wild-type (WT) …
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