目前已知cdk12有三种主要功能：（1）cdk12磷酸化rna聚合酶polⅡ，促进转录的延伸；（2）cdk12与rna加工因子相互作用，调控剪接；（3）介导伴转录的rna聚合酶Ⅱ磷酸化 …

2025年3月30日 · CDK12 (Cyclin Dependent Kinase 12) is a Protein Coding gene. Diseases associated with CDK12 include Prostate Cancer, Hereditary, 1 and Hereditary Breast Ovarian …

2021年1月27日 · cdk12是一种未来可期的癌症治疗靶标，在癌症发展中具有特定的背景作用，因此提供了一种低毒性的治疗方法。但是， 目前对cdk12生物学功能的理解被cdk12同源的cdk13 …

2020年5月25日 · Here, we discuss the diverse roles of CDK12 in gene expression regulation and human cancer, focusing on newly identified CDK12 kinase functions in cellular processes and …

CDK12 cyclin-dependent kinase 12 is a protein kinase that in humans is encoded by the CDK12 gene. [5] [6] [7] This enzyme is a member of cyclin-dependent kinase protein family.

2024年3月19日 · Cell cycle-dependent protein kinase 12 (CDK12) plays a key role in a variety of carcinogenesis processes and represents a promising therapeutic target...

Cyclin-dependent kinase 12 (CDK12) is an important transcription-associated CDK. It shows versatile roles in regulating gene transcription, RNA splicing, translation, DNA damage …

2024年12月28日 · Dysregulation of CDK12 plays a pivotal role in various stages of cancer development and progression. Overexpression or activation of CDK12 contributes to tumor …

CDK12 has been demonstrated to specifically upregulate the expression of genes involved in response to DNA damage, stress and heat shock. More recent studies have implicated CDK12 …

2024年8月18日 · Here, we show that CDK12 prevents transcription-replication conflicts (TRCs) and the activation of cytotoxic replicative stress upon deregulation of the MYC oncogene. …