Cadherin-4 is a protein that in humans is encoded by the CDH4 gene. [5][6][7] This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium-dependent cell-cell adhesion glycoprotein composed of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail.

2024年12月24日 · CDH4 (Cadherin 4) is a Protein Coding gene. Diseases associated with CDH4 include Hepatocellular Carcinoma and Seckel Syndrome. Among its related pathways are Cell junction organization and ERK Signaling. Gene Ontology (GO) annotations related to this gene include calcium ion binding. An important paralog of this gene is CDH2.

钙粘蛋白（Cadherin，简写CDH）是细胞粘附分子，在维持正常状态下的组织结构和形态方面起着重要作用，CDH的表达失调往往与疾病有关，包括组织发育不良、肿瘤形成和转移。 钙粘蛋白是钙依赖性粘附分子的超家族，至少有六个亚家族，CDH家族拥有23个成员，从CDH1到CDH26。 生理学上，钙粘蛋白有助于形成紧密连接和粘附连接，这对上皮屏障功能至关重要，调节神经系统内的突触粘附，影响学习和记忆。 病理学上，钙粘蛋白表达或功能的改变与癌症进展相关。 许 …

Based on studies in chicken and mouse, this cadherin is thought to play an important role during brain segmentation and neuronal outgrowth. In addition, a role in kidney and muscle development is indicated. Of particular interest are studies showing stable cis-heterodimers of Cadherins 2 and 4 in cotransfected cell lines.

2024年12月10日 · Official Symbol CDH4 provided by HGNC Official Full Name cadherin 4 provided by HGNC Primary source HGNC:HGNC:1763 See related Ensembl:ENSG00000179242 MIM:603006; AllianceGenome:HGNC:1763 Gene type

Cdh4 regulates cell proliferation, cell migration and tumorigenic potential of patient derived glioblastoma cells. High CDH4 expression is associated with triple-negative breast cancer. CDH4 overexpression activates c-Jun via the JNK pathway, while CDH4 knockdown suppresses both tumor xenograft growth and lung colonization.

In this study, we assessed the expression of CDH4 in MSA and control brain. We also altered CDH4 levels in oligodendrocytes and assessed its impact on α-synuclein levels. We provide evidence for a possible role of CDH4 in MSA.

Cadherin switches during epithelial-mesenchymal transition: CDH4/RCAD downregulation reduces bladder cancer progression. Regulatory CDH4 Genetic Variants Associate With Risk to Develop Capecitabine-Induced Hand-Foot Syndrome. Expression and Prognostic Significance of Cadherin 4 (CDH4) in Renal Cell Carcinoma.

CDH4是位于20号染色体的基因。 别名. 数据库编号. 该基因是钙粘蛋白超家族的经典钙黏蛋白。 编码的蛋白是一种钙依赖性细胞粘附糖蛋白，由5个胞外钙粘蛋白重复序列、一个跨膜区和高度保守的细胞质尾组成。 根据对鸡和小鼠的研究，这种钙粘蛋白被认为在脑分割和神经元生长过程中起着重要的作用。 另外，在肾脏和肌肉的发育中也有一定的作用。 特别令人感兴趣的是，研究表明，稳定的顺式二聚体钙粘蛋白2和4在共转染细胞株。 以前被认为是以纯亲性方式相互作用 …

2023年5月27日 · CDH4 is positively correlated with EMT pathway genes, negatively correlated with fatty acid metabolism pathway genes and peroxisome pathway genes, and positively correlated with ferroptosis suppressor genes in OSCC.