2022年8月30日 · Tregs是免疫抑制性T细胞，在预防自身免疫和病原体诱导的免疫病理学方面发挥关键作用，从而维持免疫稳态和自我耐受。 具有抑制活性的 CD8+ T 细胞在20世纪70年代就有人研究，然而，由于缺乏特异性标志物和基因表达调节分子，导致该研究方向一度被放弃。

2021年8月17日 · Regulatory T cells (Treg) are essential to maintain immune homeostasis and prevent autoimmune disorders. While the function and molecular regulation of Foxp3 + CD4 + Tregs are well established, much of CD8 + Treg biology remains to be revealed.

Regulatory T cells (Tregs) play a key role in the peripheral self-tolerance and preventing autoimmunity. While classical CD4 + Foxp3 + Tregs are well established, their CD8 + counterparts are still controversial in many aspects including their phenotypic identity and their mechanisms of suppression.

2024年6月10日 · Mechanistically, Treg accumulation is not caused by Treg-intrinsic inhibition of PD-1 signaling but depends on an indirect effect of activated CD8 + T cells. CD8 + T cells produce IL-2 and colocalize with Tregs in mouse and human melanomas. IL-2 upregulates the anti-apoptotic protein ICOS on tumor-Tregs, promoting their accumulation.

Despite their first recognition almost 40 years ago, CD8+ ‘suppressor’ T cells remain poorly characterized. Recent studies of these lymphocytes, now popularly referred to as regulatory CD8+ T cells (CD8+ Tregs), have helped clarify their important role in the regulation of autoimmune disease. Here, we review progress related to the identification, phenotype and function of …

CD8+ Tregs have been long described and significant progresses have been made about their phenotype, their functional mechanisms, and their suppressive ability compared to conventional CD4+ Tregs. They are now at the dawn of their clinical use. In ...

2018年3月5日 · Tumor-induced-CD8 + Treg cells could also directly modulate activation and function of immune cells. CD8 + Treg cells may play a role in promoting imbalance of the immune system in tumor growth.

2021年2月27日 · 越来越多的证据表明，CD8+T细胞的分化状态与该细胞类群的杀伤功能及其在生理和病理条件下的生存、增殖密切相关。 因此，研究CD8+T细胞的分化状态是如何决定并维持的，对于诠释该细胞类群的生理作用及研究新的抗肿瘤和抗感染策略有重大的意义。

CD4+ and CD8+ Treg subsets may also share similar cytotoxic properties with conventional Teffs. Cytotoxic effector Treg (cyTreg) are a heterogeneous population in the periphery that retain the capacity to suppress T-cell proliferation and activation, induce cellular apoptosis, and migrate to tissues to ensure immune homeostasis.

2021年8月18日 · Regulatory T cells (Treg) are essential to maintain immune homeostasis and prevent autoimmune disorders. While the function and molecular regulation of Foxp3 + CD4 + Tregs are well established, much of CD8 + Treg biology remains to be revealed. Here, we will review the heterogenous subsets of CD8 + T cells have been named "CD8 + Treg" and mainly focus on CD122 hi Ly49 + CD8 + Tregs present in ...