MHC分子、APC细胞及T细胞之间的关联及详解 - 知乎
cd8+ t细胞是一种效应性t细胞，主要负责清除感染的细胞和肿瘤细胞。 当内源性抗原被细胞自身处理后，会形成MHC-I-抗原复合物，然后与CD8+ T细胞相互作用。
MHC class II regulation of CD8 - Cell Press
2023年11月28日 · Major histocompatibility complex (MHC) class II-reactive CD8 + T cells are found in humans and animals, but little is known about their identity, development, and …
基础免疫必修课 | MHC-I 与 MHC-II 分子：肿瘤免疫中的“身份识别 …
被 cd8+ t细胞 识别 → 启动细胞毒杀伤反应。 mhc-ii：处理外源性抗原（细胞吞噬后处理） 巨噬细胞、dc、b细胞等 apc 摄取外源抗原； 在内体/溶酶体中水解降解成小片段； 与 mhc-ii 分子结 …
Nature | 改善免疫疗法的新思路——MHC II型肿瘤抗原调控机体抗 …
近日，来自美国华盛顿大学圣路易斯分校的Robert D. Schreiber团队在Nature杂志上在线发表题为MHC-II neoantigens shape tumour immunity and response to immunotherapy的文章，发现有 …
Major histocompatibility complex (MHC) class II-reactive CD8+T cells are found in humans and animals, but little is known about their identity, development, and function. In this study, we …
Present Yourself! By MHC Class I and MHC Class II Molecules
MHC I and II molecules present protein fragments to CD8+ and CD4+ T cells, respectively. These molecules are essential for cell-mediated immunity and therefore appeared at the inception of …
MHC class II-restricted antigen presentation is required to prevent ...
2023年1月12日 · Kilian et al. show that in brain tumors, loss of MHC class II drives TOX-mediated CD8+ T cell dysfunction by increased osteopontin expression. This study highlights that MHCII …
High expression of CD38 and MHC class II on CD8
In contrast to human CD8 + T cells, murine CD8 + T cells lack the transcription factor CIITA, a master regulator of H2‐Ab (MHC‐II) gene expression. 26 However, MHC‐II is highly expressed …
High expression of CD38 and MHC class II on CD8 - PubMed
2021年9月8日 · Overall, our study demonstrates that both virus-specific and bystander CD38 + MHC-II + CD8 + T cells are recruited to the site of infection during severe disease, and that …
Unexpected role for MHC II–peptide complexes in shaping CD8 T …
2012年7月7日 · Most strikingly, naïve CD8 T cells isolated from H-2M −/− mice exhibited similar hyperproliferation as MHC II −/− CD8 T cells, suggesting that peptides loaded onto MHC II …