2021年1月8日 · Here we report that CD8 + T-cell activation and anti-tumour responses are strongly potentiated by the non-essential amino acid Asn. Increased Asn levels enhance CD8 + T-cell activation and...

在CD4和CD8的胞内结构域上附着结合着Src酪氨酸激酶家族的成员—— Lck。 当TCR和多肽-MHC复合物特异性结合后，CD4和CD8也随后和MHC分子的发生结合，这导致共受体在物理上靠近TCR复合物。 与此同时在T细胞内，CD4和CD8上的Lck分子就和CD3和ξ上的ITAM靠近，随后Lck就将ITAM上的酪氨酸残基磷酸化，ITAM的磷酸化随后导致 ZAP-70 酪氨酸激酶的募集和活化，ITAM的结构中有两个酪氨酸残基，这两个酪氨酸残基被磷酸化以后可以和ZAP-70结合，结 …

2023年1月3日 · Interactions between the T cell co-receptors CD4 or CD8 and the kinase Lck safeguard T cell activation by low-affinity ligands. Meanwhile, ‘free’ Lck — which cannot bind co-receptors —...

2020年2月4日 · Our mathematical model and experimental data show that the dynamic regulation of CD4- and CD8-LCK coupling establish the self-reactivity of the peripheral T cell pool. The stoichiometry of the interaction between CD8 and LCK, but not between CD4 and LCK, substantially increases upon T cell maturation.

2022年12月23日 · The CD8-bound LCK is largely dispensable for antiviral and antitumor activity of cytotoxic T cells in mice; however, it facilitates CD8+ T cell responses to suboptimal antigens in a kinase ...

2003年9月19日 · The T cell coreceptors CD4 and CD8 both associate via their cytoplasmic tails with the N-terminus of the Src-family tyrosine kinase Lck. These interactions require zinc and are critical for T cell ...

CD4/CD8-p56 lck regulated events in T-cells include intracellular calcium mobilization, integrin activation and the induction of transcription factors for gene expression.

1999年5月5日 · Purified CD8 + naive (A and D), effector (B and E), and memory (C and F) T cells were stained for the surface expression of Vα2, fixed and permeabilized, and subsequently stained for the expression of Lck (A–C) or CD8 (D–F). All cells shown had detectable expression of the transgene-encoded TCR (not shown).

The principal role of the CD4 and CD8 co-receptors is to recruit the Src tyrosine kinase p65lck (Lck) to the TCR–pMHC complex following co-receptor binding to MHC, resulting in assembly of a TCR–pMHC–CD4 or TCR–pMHC–CD8 ternary complex (7–10). Recruitment of Lck occurs via its association with the cytoplasmic tail of CD4 or CD8.

2022年12月23日 · The CD8-bound LCK is largely dispensable for antiviral and antitumor activity of cytotoxic T cells in mice; however, it facilitates CD8+ T cell responses to suboptimal antigens in a kinase ...