2019年10月1日 · Here, we investigated whether naive MBP-specific CD8 + T cells recruited to the CNS during CD4 + T cell–initiated EAE engaged in determinant spreading and influenced disease. We found that the MBP-specific CD8 + T cells exacerbated brain but …

2021年10月29日 · Our data indicate that AE-specific CD8 + T cells accumulate in the CNS of mice with EAE where they actively contribute to disease exacerbation. We have previously shown a higher frequency of...

2015年12月10日 · In this review, we describe studies that have investigated the role of CD8(+) T-cells in MS and EAE, presenting evidence for both pathogenic and regulatory functions. In our studies, we have shown that cytotoxic/suppressor CD8(+) T-cells are CNS antigen-specific, MHC class I-restricted, IFNγ- and perforin-dependent, and are able to inhibit ...

活细胞成像研究提供cd4 + t细胞进入cns的3种可能途径，而且发现必须连续破坏两种不同的组织屏障。但近年来发现cd8 + t细胞在ms/eae发病中的重要地位，同时它们的迁移，并显示其机制与cd4 + t细胞的机制不同。

2025年2月28日 · We previously demonstrated that adoptively transferred myelin-reactive CD8 + T cells (PLP-CD8) prevent EAE induction and suppress ongoing disease through the engagement of MHC Class-I in recipient mice. Here, we show that PLP-CD8 induce regulatory changes in both subsets of conventional dendritic cells (cDC1 and CD11b + cDC) in vivo and in vitro.

2008年1月15日 · We demonstrate that the depletion of CD122 + cells increases the duration of EAE symptoms in mice and transfer of CD8 + CD122 + regulatory T cells into EAE-suffering mice dramatically diminishes EAE symptoms, indicating that CD8 + CD122 + regulatory T cells play an essential role in the recovery from EAE.

Saligrama等人研究了一种叫做实验性的多发性硬化症模型 自身免疫性脑脊髓炎 (EAE)，由注射 将髓磷脂少突胶质细胞糖蛋白 (MOG)蛋白导入小鼠。 a， 免疫 被称为CD8和CD4的细胞表达T细胞抗原受体 在它们的表面识别称为抗原的肽片段。 如果抗原 识别发生时，T细胞增殖。 在EAE，随着病情的发展， 这伴随着 CD4 T细胞 (暗红色)的增殖识别未知细胞的单核巨噬细胞和 CD8 T细胞 (深橙色) 目标。 b， 利用酵母细胞，作者筛选了一个结合肽库 小鼠主要组织相容性复合体 …

In multiple sclerosis (MS), myelin antigen-autoreactive CD4 + T cells and CD8 + T cells target and destroy myelin sheath on the nerve cells, thereby leading to substantial neuroinflammation, demyelination, axonal damage and progressive neurologic dysfunction, 1 and slowly causing permanent physical disability. 2, 3 Experimental autoimmune ...

2018年6月27日 · Purpose: Numerous nanomaterials have been reported in the treatment of multiple sclerosis or experimental autoimmune encephalomyelitis (EAE). But most of these nanoscale therapeutics deliver myelin antigens together with toxins or cytokines and underlay the cellular uptake and induction of tolerogenic antigen-presenting cells by which they ...

Polymerase chain reaction analysis suggested that both CD4(+) and CD8(+) T cells produced IFN-gamma and TNF-alpha, while CD4(+) T cells also produced interleukin-17 (IL-17), an important factor in the development of EAE. Thus, CD4(+) T cells may contribute to the induction of EAE by producing IL-17.