CD69 (C luster of D ifferentiation 69) is a human transmembrane C-Type lectin protein encoded by the CD69 gene. It is an early activation marker that is expressed in hematopoietic stem cells, T cells, and many other cell types in the immune system. [5]

CD69 is a membrane-bound, type II C-lectin receptor. It is a classical early marker of lymphocyte activation due to its rapid appearance on the surface of the plasma membrane after stimulation.

CD69 is an early leukocyte activation molecule expressed at sites of chronic inflammation. The precise role of CD69 in immunity has not been elucidated owing to the absence of a known ligand and adequate in vivo models to study its physiological function.

Mar 28, 2025 · CD69 (CD69 Molecule) is a Protein Coding gene. Diseases associated with CD69 include Coccidioidomycosis and Eosinophilic Pneumonia. Among its related pathways are Extrafollicular and follicular B cell activation by SARS-CoV-2 and Hematopoietic Stem Cells and Lineage-specific Markers.

CD69 is an early leukocyte activation marker involved in the regulation of the immune response. Initial in vitro studies evaluated its function using monoclonal antibodies until knock-out mice were developed.

Mar 17, 2025 · Explore the role of CD69 in T cell activation, immune regulation, and its impact on cytokine release, differentiation, and tolerance mechanisms.

Jan 8, 2024 · CD69 is a recognized classical marker of white blood cell activation. 1 It appears faster on the cytoplasmic membranes of activated cells than CD25 2 and is thus regarded as an early marker of lymphocyte activation. CD69 can be expressed in hematopoietic or immune cells and plays a regulatory role.

CD69 is a member of the calcium-dependent lectin superfamily of type II transmembrane receptors that is induced on T cells when activated and mediates their costimulation.

CD69 is a type II C-lectin membrane receptor with a scarce expression in resting lymphocytes that is rapidly induced upon cell activation. CD69 gene maps at human chromosome 12, and behaves as an early activation gene that contains responsive elements for the transcription factors NF-κB, ERG-1 and AP-1 (Fig. 1A).

Aug 4, 2024 · CD69, a type II transmembrane protein, is encoded by the CD69 gene located on chromosome 12. Structurally, it belongs to the C-type lectin superfamily, characterized by a carbohydrate-recognition domain.