Leukocyte surface antigen CD53 is a protein that in humans is encoded by the CD53 gene. [5] [6] The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains.

Mar 28, 2025 · CD53 (CD53 Molecule) is a Protein Coding gene. Diseases associated with CD53 include Autism Spectrum Disorder and Hematologic Cancer. Among its related pathways are Innate Immune System and 11p11.2 copy number variation syndrome. An important paralog of this gene is TSPAN9.

cd53 分子： 由该基因编码的蛋白质是跨膜 4 超家族的成员，也称为四跨膜蛋白家族。 这些成员中的大多数是细胞表面蛋白，其特征在于存在四个疏水结构域。

May 21, 2020 · 四跨膜蛋白 cd53 是四跨膜蛋白超家族的成员，仅在免疫区室中表达。 其中，B 细胞、CD4 + T 细胞、CD8 + T 细胞、树突状细胞、巨噬细胞和自然杀伤细胞都被发现在其表面表达高水平的这种蛋白质。

Tetraspanin CD53 is a member of the tetraspanin superfamily expressed exclusively within the immune compartment. Amongst others, B cells, CD4 + T cells, CD8 + T cells, dendritic cells, macrophages, and natural killer cells have all been found to …

May 21, 2020 · Tetraspanin CD53 is a member of the tetraspanin superfamily expressed exclusively within the immune compartment. Amongst others, B cells, CD4 + T cells, CD8 + T cells, dendritic cells, macrophages, and natural killer cells have all been found to express high levels of this protein on their surface.

Nov 2, 2024 · Title: CD53, a suppressor of inflammatory cytokine production, is associated with population asthma risk via the functional promoter polymorphism -1560 C>T. SNP rs6679497 in gene CD53 showed significant association with TNFalpha levels (P=0.001); no association of this SNP was observed with osteoarthritis

Jun 28, 2022 · CD53-negative T cells (Cd53 −/−) exhibit substantial proliferation defects, and Cd53 −/− mice show impaired tumor rejection and reduced IFNγ-producing T cells compared with wild-type mice. Investigation into the mechanism reveals that CD53 is required for CD45RO expression and mobility.

Familial deficiency of this gene has been linked to an immunodeficiency associated with recurrent infectious diseases caused by bacteria, fungi and viruses. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]

Aug 6, 2024 · In this study we investigated the effects of glycosylation of CD37 and CD53, two tetraspanins important for cellular and humoral immunity. Broad and cell-specific repertoires of N-glycosylated CD37 and CD53 were observed in human B cells.