2019年2月15日 · 根据CD45RA、CD45RO、CD197（CCR7）、CD62L和CD27的差异表达，可以将CD4和CD8 T细胞的功能成熟阶段主要分为4个：初始T（TN）、中央记忆T（TCM）、效应记忆T（TEM）和终末效应T（TTE），除此之外，还有两个小亚群：干细胞记忆T（TSCM）和过渡记忆T（TTM）。 以上6个功能亚群，更详细的表面标记差异，参见下表： 补充说明. CD4＋T和CD8＋T之间，一些泛T细胞相关抗原的表达强度会有所差异，例如CD4＋T的CD5强度更 …

但是，最近有关cd8+t细胞研究的结果提示记忆t细胞也表达cd45ra；某些研究结果还表明活化早期的cd8+t细胞表达cd27，而分化晚期的、穿孔素阳性的ctl不表达cd27，提示cd27表达的丢失可能是效应和记忆cd8+t细胞的一种标志（下表）。

2020年12月11日 · 通过ccr7和cd45ra，t细胞可分为四个主要亚群。 这些细胞被命名为初始细胞(N)、中央记忆细胞(CM)、效应记忆细胞(EM)和重新表达CD45RA的终末分化效应记忆细胞(TEMRA)，尽管体内也可能存在一些中间亚群。

2025年2月7日 · CD45RA is a critical protein isoform in the immune system, influencing T-cell function and differentiation. Understanding its role is essential for comprehending various immunological processes and potential implications in disease.

CD45RA T cells have "naive" characteristics of unresponsiveness to recall antigens and prominence in cord blood, while CD45RO T cells are considered "memory" T cells because they proliferate to recall antigens and increase following PHA activation of cord blood.

CD45RA+T细胞被称为“原始”T淋巴细胞，即未致敏T细胞，具有抑制免疫的作用；而CD45RO+T细胞被称为“记忆”T细胞，具有辅助诱导免疫的作用。 CD45RA/CD45RO有助于判断乙型肝炎患者的免疫状况，辅助指导治疗和预后。 研究发现相较于正常对照组，慢性乙型肝炎患者组外周血CD8+CD45RA+T细胞明显降低，而CD8+CD45RO+T细胞明显增高。 重度慢性乙型肝炎患者与轻中度慢性乙型肝患者相比，CD8+CD45RA+T细胞明显降低，CD8+CD45RO+T细胞明显升 …

2017年11月13日 · However, a subset of effector memory T cells re-expresses CD45RA (termed TEMRA) after antigenic stimulation with unknown molecular characteristics and functions. CD4 TEMRA cells have been...

Naïve T-cells express the isoform CD45RA and the isoform CD45RO is primarily found on primed/memory T-cells. By flow cytometric assays using fluorochrome conjugated antibodies against CD45RA and CD45RO, there is a typical staining pattern seen within the CD4+ T lymphocyte and CD8+ T lymphocyte compartments (see reference cases in Figure 1 ).

CD45RA expression identifies naive CD4 + CD25 + Treg with an enhanced stability of Treg phenotype. We combine an analysis of CD45RA, CD25, and CD127 expression to identify subpopulations of CD4 + CD127 −/lo CD25 + cells.

We have investigated the differences in the proximal signaling induced by anti-CD3 monoclonal antibody in purified populations of "naive" CD45RA+ and "memory" CD45RO+ human CD4+ T cells. Expression of cell surface CD3, CD4 and CD28 was …