必追的国自然热点：CD4 + T细胞在抗肿瘤免疫中的作用 - 知乎
通常只有CD8+T细胞被认为具有消灭肿瘤的作用，但临床研究已发现肿瘤中的CD4+T细胞也具有细胞毒性。 本文回顾癌症背景下，细胞毒性CD4+T细胞的发育、作用和特征。 强调通过研究细 …
CD4 + T cell-induced inflammatory cell death controls immune
2023年6月14日 · CD4+ T-cell-derived IFNγ sensitises IFN-responsive melanoma cells for TNF-induced cell death. Myeloid cell-derived nitric oxide (NO) contributes to inflammatory cell death …
肿瘤坏死因子α(TNF-α)作用机制及生物学研究 - 知乎
TNF-α即 肿瘤坏死因子α ，也被称作 cachectin 和 TNFSF1A ，是TNF超家族的配体。它是一种多效细胞分子，在炎症、细胞凋亡和免疫系统发育中起着核心作用。
TNF-α blockade induces IL-10 expression in human CD4+ T cells
2014年2月4日 · Here we demonstrate that TNF inhibitor (TNFi) drugs induce the anti-inflammatory cytokine IL-10 in CD4+ T cells including IL-17+ CD4+ T cells. TNFi-mediated …
CD4 + T cell memory - Nature
2023年5月8日 · Tumor-infiltrating CD4 + T cells kill cancer cells, destroy tumor vessels and sustain leukocyte responses mainly through the secretion of IFNγ, TNF and IL-2 (ref. 174). …
一直被低估的CD4+ T细胞抗肿瘤作用 - 知乎 - 知乎专栏
CD4+ T细胞：CD4+ T细胞通过分化为不同的亚群（如Th1、Th2、Th17和Treg）来调节免疫应答。 Th1细胞主要产生干扰素γ（IFN-γ），促进细胞介导的免疫反应，包括增强CTL对肿瘤细胞 …
The dichotomous outcomes of TNFα signaling in CD4 + T cells
2022年11月16日 · TNFa is a pleiotropic cytokine that has both proinflammatory and regulatory effects on CD4 + T cells and can influence the adaptive immune response against …
TNF-α signals through ITK-Akt-mTOR to drive CD4 - Science
2024年4月23日 · We found that tumor necrosis factor–α (TNF-α) released by human naïve CD4 + T cells upon activation stimulated the expression of a metabolic transcriptome and increased …
T-cell-derived IFN-γ suppresses T follicular helper cell ...
6 天之前 · CD4 + T cells play a critical role in antiviral humoral and cellular immune responses. We have previously reported that subcutaneous lymphocytic choriomeningitis virus (s.c. …
TNF-α signals through ITK-Akt-mTOR to drive CD4 - PubMed
2024年4月24日 · We found that tumor necrosis factor-α (TNF-α) released by human naïve CD4 + T cells upon activation stimulated the expression of a metabolic transcriptome and increased …