022071 B6.Cg-Tg(Cd4-cre)1Cwi/BfluJ This strain ships with remnant UID MiniMax microchips implanted subcutaneously in the back. For more information on these RFID chips, including our FAQ, please visit our Mouse Identification page . CD4-Cre transgenic mice contain CD4 enhancer, promoter and silencer sequences driving the expression of a Cre ...

2020年3月4日 · CD4 Cre表示CD4基因启动子驱动Cre重组酶表达，又因为在T细胞发育的早期有一个CD4CD8双阳的阶段，所以CD4Cre也可以理解为在T细胞中都能表达Cre酶的实验鼠。

CD4主要由辅助T（Th）细胞表达，是Th细胞TCR识别 抗原 的受体，与MHCⅡ类分子的非多肽区结合，参与Th细胞TCR识别抗原过程；CD4也是HIV的主要受体，由于艾滋病病毒攻击对象是CD4细胞，所以其检测结果对艾滋病诊断、治疗效果的判断和对患者免疫功能的判断有着重要作用。 用来跟flox小鼠杂交，实现Cd4表达细胞的特异性目的基因敲除。

2024年6月19日 · 以下是一些在免疫研究中重要的Cre小鼠品系（依名称字母排序）及相关的参考论文： 1. CD4-Cre. 简介：CD4主要在辅助性T细胞中表达。 应用： • 用于研究辅助性T细胞的发育、分化和功能。 • T细胞特异性基因敲除，研究T细胞介导的免疫反应。 Lee, P.P., et al. (2001).

CD4-Cre deletes floxed sequences in both CD4 and CD8 T cells. To delete floxed genes only in peripheral CD8 but not CD4 T cells, CD8a–Cre (Maekawa et al., 2008), also known as E8I–Cre, may be used.

2016年9月1日 · Here we describe a dose-dependent effect of continued CRE recombinase expression on CD4 + T cell numbers and frequencies in the spleen, provide the location of the insertion, the number of inserted copies of the Cre transgene, and …

We propose that caKRas-CD4Cre mice represent a novel model of proliferative pneumonia involving macrophages and epithelial cells, and that the CD4Cre model may offer unique utility for studying gene functions simultaneously in multi-lineages in the lung.

Cre recombinase is expressed under the control of mouse Cd4 regulatory elements. The Cd4 enhancer, promoter and silencer collectively drive expression at sequential stages specifically of CD4+ T cell development.

2024年6月23日 · CD4-cre小鼠介绍. T细胞特异表达cre，与带有两个FloxP位点的FloxP小鼠交配后，在Cre特异表达的组织或者器官或细胞中，目标基因中两个FloxP位点间的外显子或元件将被删除，达到条件性敲除或过表达的目的。

The CD4-Cre Microinjected Mouse uses the mouse Cd4 promoter/enhancer/silencer, which first allows expression of CD4 as thymocytes enter the double positive stage. The silencer region extinguishes transgene expression at the double negative stage as well as in …