Concise Review: Evidence for CD34 as a Common Marker for …
CD34 is a transmembrane phosphoglycoprotein, first identified on hematopoietic stem and progenitor cells. Clinically, it is associated with the selection and enrichment of hematopoietic stem cells for bone marrow transplants. Due to these historical ...
CD34—Structure, Functions and Relationship with Cancer Stem Cells
CD34 is primarily known as a biomarker for hematopoietic stem cells (HSCs) and hematopoietic stem precursor cells, but it has also been identified as a marker for several non-hematopoietic cells.
Not just a marker: CD34 on human hematopoietic stem/progenitor cells ...
2017年12月26日 · CD34 is routinely used to identify and isolate human hematopoietic stem/progenitor cells (HSPCs) for use clinically in bone marrow transplantation, but its function on these cells remains elusive. Glycoprotein ligands on HSPCs help guide their migration to specialized microvascular beds in the bone marrow that express vascular selectins (E- and ...
Who is hematopoietic stem cell: CD34+ or CD34-? - PubMed
CD34 is a marker of human HSC, and all colony-forming activity of human bone marrow (BM) cells is found in the CD34+ fraction. Clinical transplantation studies that used enriched CD34+ BM cells indicated the presence of HSC with long-term BM reconstitutional ability within this fraction.
CD34 - an overview | ScienceDirect Topics
CD34 is a transmembrane glycoprotein that is expressed on early lymphohematopoietic stem cells, progenitor cells, endothelial cells, embryonic fibroblasts, and some cells in fetal and adult nervous tissue. It is also expressed on pluripotent and committed stem cells in …
CD34 Gene - GeneCards | CD34 Protein | CD34 Antibody
2024年10月1日 · CD34 (CD34 Molecule) is a Protein Coding gene. Diseases associated with CD34 include Dermatofibrosarcoma Protuberans and Angiosarcoma. Among its related pathways are Innate Immune System and Class I MHC mediated antigen processing and presentation.
Endothelial CD34 expression and regulation of immune cell …
2023年8月19日 · The sialomucin, CD34, is widely used as an endothelial marker. However, CD34 is differentially expressed on endothelial cells in different organs and in pathological conditions.
Human CD34 - American Society of Hematology
2023年8月10日 · Hematopoietic stem cell markers and their potential signaling interactions governing their biology. A schematic diagram of potential signaling pathways downstream of key markers expressed on CD34 + (CD38/CD45RA) – EPCR + HSCs (which are also CD49f + and CD90 + / −) upon interacting with their potential ligands in the niche.
CD34+ or CD34−: Does it Really Matter? | Blood | American …
1999年10月15日 · THE CELL SURFACE glycoprotein CD34 has been the focus of intense interest ever since its discovery on a small fraction of human bone marrow cells.1 The CD34 + population appears responsible for most, if not all, of the hematopoietic activity in bone marrow, including colony formation in short-term assays,1 the maintenance of long-term in vitro ...
A sticky wicket: Defining molecular functions for CD34 in hematopoietic …
CD34, one of the best known and clinically important markers of hematopoietic progenitor cells, was first identified as a surface antigen expressed on the myeloblastic cell line KG-1a and a subpopulation (1%–2%) of “normal” human bone marrow (BM) containing most (∼95%) of the myeloid and erythroid lineage-committed progenitors [1].
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