CD32 (cluster of differentiation 32), also known as FcγRII or FCGR2, is a surface receptor glycoprotein belonging to the Ig gene superfamily. [2] CD32 can be found on the surface of a variety of immune cells. [2] [3] CD32 has a low-affinity for the Fc region of IgG antibodies in monomeric form, but high affinity for IgG immune complexes. [4]CD32 has two major functions: cellular response ...

FcγRII (CD32) FcγRII有三种形式，FcγRIIa、FcγRIIb、FcγRIIc；FcγRIIa主要在中性粒细胞、单核细胞、DC细胞表面表达；FcγRIIc 主要在单核巨噬细胞、中性粒细胞和NK细胞表面表达；FcγRIIb的结构较特殊，其胞内结构域串联了一个ITIM结构（见上图），介导的是免疫抑制信号 ...

cd32. fc γrii、fcgr2a、fcgr2b. b 细胞、单核细胞、粒细胞、血小板和内皮细胞。 调控 b 细胞的功能，诱导吞噬作用和介质释放。 cd33. 唾液酸结合性免疫球蛋白样凝集素 3、siglec3. 单核细胞、粒细胞、肥大细胞和髓系祖细胞。

2019年3月18日 · The human FcγRII family (also known as CD32 in the Cluster of Differentiation nomenclature) consists of a family of primarily cell membrane receptor proteins. They are encoded by the mRNA splice variants of three highly related genes— FCGR2A, FCGR2B , and FCGR2C , which arose by recombination of the FCGR2A and FCGR2B genes ( 3 ).

2024年4月9日 · Scarfò, Randolph et al. perform transcriptomic analysis of 28- to 32-day human embryos and identify CD32 as a marker of haemogenic endothelial cells (HECs), thus providing a strategy to isolate ...

2018年7月16日 · CD32 is a marker of T-cell activation. We evaluated CD32 expression in purified primary CD4+ T cells from HIV− control donors under different activating conditions, including PHA/IL-2, an anti ...

Negative Regulation of BCR Signaling via CD22 and CD32. CD22 is a B cell–specific member of the Siglec (sialic acid–binding Ig-lectins) family of transmembrane proteins, whereas CD32 (FcɣRIIB) is a low-affinity receptor for the Fc region of antigen-aggregated IgG. Both receptors regulate BCR signaling via cytoplasmic tyrosine phosphorylation motifs, which form the so-called immunoreceptor ...

IFN-γ可刺激单核细胞、巨噬细胞和中性粒细胞表达FcγRⅠ水平增加5～10倍，G-CSF也有这种促进作用。 （2）FcγRⅡ（CD32）：40kDa穿膜糖蛋白，属于Ig超家族成员，胞膜外区有2个C2结构，基因染色体定位于1q23～24。识别CD32的代表性McAb有CIkM5、IV·3、KuFc79和41H16等。

CD32, CD32A, CDw32, FCG2, FCGR2, FCGR2A1, FcGR, FcgammaRIIa, IGFR2 Chromosome: 1; Location: 1q23.3. Tests; Conditions; OMIM; More about this gene; 2. FCGR2B - Fc gamma receptor IIb. The protein encoded by this gene is a low affinity receptor for the Fc region of immunoglobulin gamma complexes. The encoded protein is involved in the phagocytosis ...

中医书籍《细胞和分子免疫学》“（一）FcγR（CD64、CD32、CD16）”：1.FcγR的结构和分布 FcγR可分为FcγRⅠ、FcγRⅡ和FcγRⅢ三类，它们的结构和分布有所不同。（1）FcγRⅠ（CD64）：70kDa穿膜糖蛋白，属Ig超家族成员，胞膜外区有3个C2结构，基因染色体定位于1q23～24。