Pathology Outlines - Classic Hodgkin lymphoma
2021年12月1日 · Immunostains show that the large abnormal cells are positive for PAX5 (weak), CD30 and CD15 (subset) and are negative for CD20, CD45 and CD3. In situ hybridization for EBV encoded RNA (EBER) is negative. CD3 highlights background small T cells. Flow cytometry showed polytypic B cells and mixed T cells subsets.
Pathology Outlines - Peripheral T cell lymphoma, NOS
2020年5月18日 · By paraffin immunohistochemistry, the tumor cells are positive for CD3, CD4, CD5 and CD30 (subset, variable intensity) while negative for CD20, CD7, CD8, CD15, TIA1, granzyme B, perforin, CD10, BCL6, PD1, CXCL13, CXCR5 and EBER ISH. PCR studies are positive for clonal TCR gene rearrangement.
Pathology Outlines - T cell large granular lymphocytic leukemia
2020年1月13日 · Mature CD3 positive T cells, usually coexpress NK cell associated markers (CD16 and CD57), with variable expression of other pan T cell markers such as CD2, CD5, CD7; 25% of cases are KIR restricted CD4- CD8+ T cell type being the most common, followed by TCRγδ+ T cell type, CD4+ CD8- T cell type, TCRαβ+ CD4- CD8- T cell type and rarely ...
Follicular peripheral T cell lymphoma (F-PTCL)
2022年1月13日 · The neoplastic cells are medium sized with clear cytoplasm and irregular nuclei. A CD3 stain highlights interfollicular aggregates of neoplastic T cells with coexpression of Tfh markers: PD-1, ICOS and CXCL13. CD20 immunostain reveals numerous follicles as well as interfollicular IgD positive B cells, which surround neoplastic T cells.
Pathology Outlines - Lymphoid aggregates (benign)
2023年11月15日 · Abnormal T cell phenotype is described by abnormal expression patterns of T cell markers; for example, downregulation of surface CD3 expression, loss of CD7 or CD5 as well as a skewed CD4:CD8 ratio or expansion of double positive (CD4+ / CD8+) or double negative (CD4- / CD8-) populations
Pathology Outlines - CD38
2023年5月18日 · Comment: The needle core biopsy demonstrates a dense infiltration by a clonal plasma cell population with kappa light chain restriction. The neoplastic plasma cells are positive for CD38, CD138 and CD79a. Lambda light chains, CD20 and CD43 are not expressed. There are only scattered CD3 positive T cells. There is no amyloid deposition.
Pathology Outlines - Indolent T lymphoblastic proliferations
3 天之前 · Interspersed within the paracortical areas are increased CD3+ / TdT+ positive T cells without aberrant antigen expression. The presence of immature T cells in association with hyaline vascular Castleman disease has been reported and typically shows indolent behavior. Clinical correlation is recommended. (Am J Surg Pathol 2012;36:1619)
Pathology Outlines - Lymphoid polyp
2024年3月27日 · Comment: The mucosal lymphoid tissue shows polymorphous population of lymphoid tissue. There is an admixture of CD20 positive B cells and CD3 positive T cells. CD45 stain shows no aberrant expression in the regions stained by CD20. Note: Immunohistochemical stains are not required for the majority of cases.
Pathology Outlines - Lymphocytic gastritis
2023年7月27日 · Most cases show around 35 - 75 surface intraepithelial lymphocytes per 100 epithelial cells (Gut 1990;31:282) Lymphoplasmacytic expansion of the lamina propria can be additionally seen Intraepithelial neutrophils may be seen, especially in the setting of H. pylori infection or mucosal erosion
Primary cutaneous acral CD8+ lymphoproliferative disorder
2022年11月11日 · CD8, CD3, TIA1 (focal), granzyme B (commonly negative; focal occasionally), T cell receptor BF1; Characteristic dot-like pattern of CD68 expression (negativity doesn't exclude the diagnosis) (Br J Dermatol 2022;186:887) Aberrant loss of CD2, CD5 and CD7 may be present in a proportion of the atypical lymphocytes
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