cd28主要作为“第二信号”（与靶细胞表面的b7-1/ b7-2结合）降低有效活化t细胞所需的阈值，强化激活t细胞的“第一信号”（t细胞受体（tcr）- cd3复合物对靶细胞的mhc-多肽识别和结合），使t细胞进一步发育，增殖为具有免疫功能的细胞。

2021年3月24日 · 在本期推送中，我们介绍了B7与T细胞上的CD28结合产生阳性的激活信号，激活T细胞，增强免疫应答；B7与CTLA-4结合时产生阴性信号，抑制T细胞的活化，下调免疫反应。 注：图片来源于参考书及网络。 文章无商业用途，仅用来传递知识，如有版权问题，联系删除。 如因版权等有疑问，请于本文刊发30日内联系药学速览。 原创内容未经授权，禁止转载至其他平台。 有问题可发邮件至[email protected]获取更多信息。 ©2020 药学速览 保留所有权利.

2024年2月13日 · In this review, Sharpe and colleagues review inhibitory members of the B7-CD28 family and their roles in regulating immune responses with an emphasis on CTLA-4, PD-1, and the increasingly complex network of cis and trans interactions with their ligands in lymphoid organs and the periphery with implications for infection, autoimmunity, and anti ...

2002年2月1日 · New B7 and CD28 family members and new pathways have recently been identified that seem to be especially important for regulating the responses of previously activated, rather than...

The CD28/B7 receptor/ligand system is one of the dominant costimulatory pathways. Interruption of this signaling pathway with CD28 antagonists not only results in the suppression of the immune response, but in some cases induces antigen-specific tolerance.

2023年4月17日 · The B7/CD28 families of immune checkpoints play vital roles in negatively or positively regulating immune cells in homeostasis and various diseases.

2024年2月13日 · Costimulatory pathways within the B7:CD28 family provide essential signals for optimal T cell activation and clonal expansion. They provide crucial inhibitory signals that maintain immune homeostasis, control resolution of inflammation, regulate host defense, and promote tolerance to prevent autoimmunity.

2013年6月19日 · In this study, we describe a new receptor–ligand interaction in the B7/CD28 family, between CD28H and B7 homologue 5 (B7-H5). CD28H is constitutively expressed on naive T cells while its...

The B7-1/B7-2-CD28/CTLA-4 pathway is crucial in regulating T-cell activation and tolerance. New B7 and CD28 molecules have recently been discovered and new pathways have been delineated that seem to be important for regulating the responses of previously activated T cells. Several B7 homologues are …

2021年5月14日 · B7-1/B7-2是最早发现的两个B7家族成员，受体CTLA-4和CD28与二者互作，调控T细胞状态，进而调节机体免疫。 但是B7-2和CD28表现为正调节信号，B7-1表现为负调节信号。 百时美施贵宝的2款融合蛋白药物已经批准上市，辉瑞、康宁杰瑞均有此靶点研发布局。 B7-H1即为我们熟知的PD-L1, PD1/PD-L1是经典的协同抑制信号途径，目前批准上市的药物更是百花齐放，罗氏Tecentriq 阿特珠单抗是 FDA批准的第一个PD-L1药物，获批的药物还有默克/辉瑞 …